CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014632
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome P450 4B1 
Protein Synonyms/Alias
 CYPIVB1 
Gene Name
 Cyp4b1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
51DSFPGPPKHWLFGHAubiquitination[1]
63GHALEIQKTGGLDKVubiquitination[1]
482EFSPDPSKIPIKVPQubiquitination[1]
486DPSKIPIKVPQLILRubiquitination[1]
495PQLILRSKNGIHLYLubiquitination[1]
503NGIHLYLKPLGPGSGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Responsible for mutagenic activation of 3-methoxy-4- aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2-aminofluorene and 2-aminoanthracene. 
Sequence Annotation
 METAL 453 453 Iron (heme axial ligand) (By similarity).
 BINDING 315 315 Heme (covalent; via 1 link) (By  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 511 AA 
Protein Sequence
MALSFLSPSL SRLGLWASVV ILMVTVLKLL SLLFRRQKLA RALDSFPGPP KHWLFGHALE 60
IQKTGGLDKV VTWTEQFPYA HPLWLGQFIV FLNIYEPDYA KAVYSRGDPK AAYVYDFFLQ 120
WIGKGLLVLE GPKWFQHRKL LTPGFHYDVL KPYVAIFAES TRVMLDKWEK KASENKSFDI 180
FCDVGHMALD TLMKCTFGKG DSGLSHSDNS YYLAVSDLTL LMQQRIDSFQ YHNDFIYWLT 240
PHGRRFLRAC QIAHDHTDHV IRQRKAALQD EKEQKKLQER RHLDFLDILL GARDESGIKL 300
SDADLRAEVD TFMFEGHDTT TSGISWFLYC MALYPMHQQR CREEVREILG DRDSFQWDDL 360
AQMTYLTMCM KECFRLYPPV PQVYRQLSKP VTFVDGRSLP AGSLISLHIY ALHRNSAVWP 420
DPEVFDPLRF SPENMTGRHP FAFMPFSAGP RNCIGQQFAM NEMKVVTALC LLRFEFSPDP 480
SKIPIKVPQL ILRSKNGIHL YLKPLGPGSG K 511 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0018585; F:fluorene oxygenase activity; IEA:Compara.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0018879; P:biphenyl metabolic process; IEA:Compara.
 GO:0042738; P:exogenous drug catabolic process; IEA:Compara.
 GO:0018917; P:fluorene metabolic process; IEA:Compara. 
Interpro
 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I. 
Pfam
 PF00067; p450 
SMART
  
PROSITE
 PS00086; CYTOCHROME_P450 
PRINTS
 PR00463; EP450I.
 PR00385; P450.