UniProt Accession

 CCS_HUMAN; O14618; Q2M366 

Genbank Protein ID

 AF002210; CR541928; BC105016; BC112055 

Genbank Nucleotide ID

 AAC51764.1; CAG46726.1; AAI05017.1; AAI12056.1 

Protein Name

 Copper chaperone for superoxide dismutase 

Protein Synonyms/Alias

 Superoxide dismutase copper chaperone 

Gene Name

 CCS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	TGRQAVLKGMGSGQL	ubiquitination	[1]
189	RMEDEQLKVWDVIGR	ubiquitination	[1]
216	RGGHPLSKITGNSGE	ubiquitination	[1]
241	AGLFQNPKQICSCDG	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Delivers copper to copper zinc superoxide dismutase (SOD1). 

Sequence Annotation

 DOMAIN 12 75 HMA.
 REGION 88 234 Superoxide dismutase-like.
 METAL 22 22 Copper 1.
 METAL 25 25 Copper 1.
 METAL 147 147 Zinc.
 METAL 155 155 Zinc.
 METAL 164 164 Zinc.
 METAL 167 167 Zinc.
 METAL 244 244 Copper 2.
 METAL 246 246 Copper 2.
 MOD_RES 267 267 Phosphoserine (By similarity).
 DISULFID 141 227
 CROSSLNK 76 76 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 189 189 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 216 216 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 241 241 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Chaperone; Complete proteome; Copper; Cytoplasm; Disulfide bond; Isopeptide bond; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Ubl conjugation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005743; C:mitochondrial inner membrane; IBA:RefGenome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005375; F:copper ion transmembrane transporter activity; TAS:ProtInc.
 GO:0004784; F:superoxide dismutase activity; IBA:RefGenome.
 GO:0016532; F:superoxide dismutase copper chaperone activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IBA:RefGenome.
 GO:0015680; P:intracellular copper ion transport; IBA:RefGenome.
 GO:0051353; P:positive regulation of oxidoreductase activity; IEA:Compara.
 GO:0019430; P:removal of superoxide radicals; IBA:RefGenome. 

Interpro

 IPR006121; HeavyMe-assoc_HMA.
 IPR024134; SOD_Cu/Zn_/chaperones.
 IPR018152; SOD_Cu/Zn_BS.
 IPR024142; SOD_Cu_chaperone.
 IPR001424; SOD_Cu_Zn_dom. 

Pfam

 PF00403; HMA
 PF00080; Sod_Cu 

SMART

  

PROSITE

 PS01047; HMA_1
 PS50846; HMA_2
 PS00087; SOD_CU_ZN_1
 PS00332; SOD_CU_ZN_2 

PRINTS

 PR00068; CUZNDISMTASE.