CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026622
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diaminopimelate decarboxylase 
Protein Synonyms/Alias
 DAP decarboxylase; DAPDC 
Gene Name
 lysA 
Gene Synonyms/Alias
 RPA4741 
Created Date
 July 27, 2013 
Organism
 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 
NCBI Taxa ID
 258594 
Lysine Modification
Position
Peptide
Type
References
106IVFSGVGKTEAELRAacetylation[1]
Reference
 [1] System-wide studies of N-lysine acetylation in Rhodopseudomonas palustris reveal substrate specificity of protein acetyltransferases.
 Crosby HA, Pelletier DA, Hurst GB, Escalante-Semerena JC.
 J Biol Chem. 2012 May 4;287(19):15590-601. [PMID: 22416131] 
Functional Description
 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity). 
Sequence Annotation
 REGION 275 278 Pyridoxal phosphate binding (By
 BINDING 239 239 Pyridoxal phosphate; via amide nitrogen
 BINDING 278 278 Substrate (By similarity).
 BINDING 314 314 Substrate (By similarity).
 BINDING 318 318 Substrate (By similarity).
 BINDING 347 347 Substrate (By similarity).
 BINDING 375 375 Pyridoxal phosphate (By similarity).
 BINDING 375 375 Substrate (By similarity).
 MOD_RES 60 60 N6-(pyridoxal phosphate)lysine (By  
Keyword
 Amino-acid biosynthesis; Complete proteome; Decarboxylase; Lyase; Lysine biosynthesis; Pyridoxal phosphate. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 421 AA 
Protein Sequence
MRHFDYRDGV LHAEGVSLAS IAQDVGTPFY CYSSATLERH YRVFTEAFAG LDALVCYAMK 60
ANSNQSVLRT LAKLGAGADV VSGGELQRAL AAGIPPSKIV FSGVGKTEAE LRAALDHDIK 120
CLNVESEPEL EQLSRIAVET GRTARISLRV NPDVDSGTHA KISTGKSENK FGIPIRHARE 180
VYARAAKLPG IQVTGVDVHI GSQIIDLAPM EAAFRKVAEF IHVLRGDGHT VNHVDFGGGL 240
GIPYYEDRDA PPEPFAYAEM VKRVTHNLGC TLLFEPGRMI VGNAGILVAK VIYVKHGDGK 300
TFVIIDAAMN DLIRPTLYEA YHEILPVAAP APGVATMVAD VVGPVCETGD YLALDRKLPE 360
LKAGDLIAIM TAGAYGAVQA CTYNTRALVP EVLVKDDQVA VVRPRIEVEQ LIAMDKPAPW 420
L 421 
Gene Ontology
 GO:0008836; F:diaminopimelate decarboxylase activity; IEA:HAMAP.
 GO:0030170; F:pyridoxal phosphate binding; IEA:HAMAP.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP. 
Interpro
 IPR009006; Ala_racemase/Decarboxylase_C.
 IPR002986; DAP_deCOOHase_LysA.
 IPR022643; De-COase2_C.
 IPR022644; De-COase2_N.
 IPR022653; De-COase2_pyr-phos_BS.
 IPR000183; Orn/DAP/Arg_de-COase. 
Pfam
 PF02784; Orn_Arg_deC_N
 PF00278; Orn_DAP_Arg_deC 
SMART
  
PROSITE
 PS00878; ODR_DC_2_1 
PRINTS
 PR01181; DAPDCRBXLASE.
 PR01179; ODADCRBXLASE.