| Tag | Content |
|---|
| CPLM ID | CPLM-020633 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 11 |
Protein Synonyms/Alias | Int11; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein |
Gene Name | Cpsf3l |
Gene Synonyms/Alias | Ints11 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 500 | VSSEQALKELGLAEH | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage (By similarity). |
Sequence Annotation | MOTIF 68 73 HXHXDH motif. |
Keyword | Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 600 AA |
Protein Sequence | MPEIRVTPLG AGQDVGRSCI LVSISGKNVM LDCGMHMGYN DDRRFPDFSY ITQSGRLTDF 60
LDCVIISHFH LDHCGALPYF SEMVGYDGPI YMTHPTQAIC PILLEDYRKI AVDKKGEANF 120
FTSQMIKDCM KKVVAVHLHQ TVQVDDELEI KAYYAGHVLG AAMFQIKVGS ESVVYTGDYN 180
MTPDRHLGAA WIDKCRPNLL ITESTYATTI RDSKRCRERD FLKKVHETVE RGGKVLIPVF 240
ALGRAQELCI LLETFWERMN LKVPIYFSTG LTEKANHYYK LFITWTNQKI RKTFVQRNMF 300
EFKHIKAFDR TFADNPGPMV VFATPGMLHA GQSLQIFRKW AGNEKNMVIM PGYCVQGTVG 360
HKILSGQRKL EMEGRQMLEV KMQVEYMSFS AHADAKGIMQ LVGQAEPESV LLVHGEAKKM 420
EFLRQKIEQE FRVSCYMPAN GETVTLPTSP SIPVGISLGL LKREMVQGLL PEAKKPRLLH 480
GTLIMKDSNF RLVSSEQALK ELGLAEHQLR FTCRVHLQDT RKEQETALRV YSHLKSTLKD 540
HCVQHLPDGS VTVESILIQA AAHSEDPGTK VLLVSWTYQD EELGSFLTTL LKNGLPQAPS 600 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |