CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018837
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coronin-2A 
Protein Synonyms/Alias
 IR10; WD repeat-containing protein 2 
Gene Name
 CORO2A 
Gene Synonyms/Alias
 IR10; WDR2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
114IKIWSIPKQLLTRNLubiquitination[1]
320YRSYNPQKGIGVMPKubiquitination[1]
342CEIFRFYKLITTKSLubiquitination[1]
347FYKLITTKSLIEPISubiquitination[1]
432RLLNQTEKLAAEDGWubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 REPEAT 80 120 WD 1.
 REPEAT 130 170 WD 2.
 REPEAT 178 217 WD 3.
 REPEAT 220 263 WD 4.
 REPEAT 269 308 WD 5.  
Keyword
 Actin-binding; Coiled coil; Complete proteome; Polymorphism; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 525 AA 
Protein Sequence
MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF 60
LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS CSEDATIKIW SIPKQLLTRN 120
LTAYRKELVG HARRVGLVEW HPTAANILFS AGYDYKVMIW NLDTKESVIT SPMSTISCHQ 180
DVILSMSFNT NGSLLATTCK DRKIRVIDPR AGTVLQEASY KGHRASKVLF LGNLKKLMST 240
GTSRWNNRQV ALWDQDNLSV PLMEEDLDGS SGVLFPFYDA DTSMLYVVGK GDGNIRYYEV 300
SADKPHLSYL TEYRSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI EPISMIVPRR 360
SESYQEDIYP PTAGAQPSLT AQEWLSGMNR DPILVSLRPG SELLRPHPLP AERPIFNSMA 420
PASPRLLNQT EKLAAEDGWR SSSLLEEKMP RWAAEHRLEE KKTWLTNGFD VFECPPPKTE 480
NELLQMFYRQ QEEIRRLREL LTQREVQAKQ LELEIKNLRM GSEQL 525 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IBA:RefGenome.
 GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
 GO:0051015; F:actin filament binding; IBA:RefGenome.
 GO:0030036; P:actin cytoskeleton organization; IBA:RefGenome.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc. 
Interpro
 IPR027335; CORO2A.
 IPR015505; Coronin.
 IPR015048; DUF1899.
 IPR015049; DUF1900.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08953; DUF1899
 PF08954; DUF1900
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS