UniProt Accession

 INAR1_HUMAN; P17181; B2R6L9; D3DSF0; Q53GW9; Q53H11; Q6PKD7; Q7M4L2; Q8WTZ2 

Genbank Protein ID

 J03171; X60459; AK312631; AK222770; AK222812; AY654286; AF039907; AP000296; AP000297; AP000298; CH471079; CH471079; BC002590; BC021825 

Genbank Nucleotide ID

 AAA52730.1; CAA42992.1; BAG35516.1; BAD96490.1; BAD96532.1; AAT49100.1; EAX09837.1; EAX09839.1; AAH02590.1; AAH21825.1 

Protein Name

 Interferon alpha/beta receptor 1 

Protein Synonyms/Alias

 IFN-R-1; IFN-alpha/beta receptor 1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1 

Gene Name

 IFNAR1 

Gene Synonyms/Alias

 IFNAR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
86	CQNITSTKCNFSSLK	ubiquitination	[1]
125	DSFTPFRKAQIGPPE	ubiquitination	[1]
278	GNHLYKWKQIPDCEN	ubiquitination	[1]
397	DVTVPNLKPLTVYCV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. 

Sequence Annotation

 DOMAIN 134 224 Fibronectin type-III 1.
 DOMAIN 230 326 Fibronectin type-III 2.
 DOMAIN 334 425 Fibronectin type-III 3.
 MOD_RES 466 466 Phosphotyrosine; by TYK2 (Probable).
 MOD_RES 481 481 Phosphotyrosine; by TYK2 (Probable).
 MOD_RES 495 495 Phosphoserine.
 LIPID 463 463 S-palmitoyl cysteine.
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 58 58 N-linked (GlcNAc...).
 CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).
 CARBOHYD 88 88 N-linked (GlcNAc...) (Potential).
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 172 172 N-linked (GlcNAc...).
 CARBOHYD 254 254 N-linked (GlcNAc...) (Potential).
 CARBOHYD 313 313 N-linked (GlcNAc...).
 CARBOHYD 314 314 N-linked (GlcNAc...) (Potential).
 CARBOHYD 376 376 N-linked (GlcNAc...) (Potential).
 CARBOHYD 416 416 N-linked (GlcNAc...) (Potential).
 CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
 DISULFID 79 87
 DISULFID 199 220
 DISULFID 283 291  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 557 AA 

Protein Sequence

Gene Ontology

 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0004905; F:type I interferon receptor activity; TAS:ProtInc.
 GO:0051607; P:defense response to virus; IEA:Compara.
 GO:0007259; P:JAK-STAT cascade; TAS:ProtInc.
 GO:0032729; P:positive regulation of interferon-gamma production; IEA:Compara.
 GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.
 GO:0009615; P:response to virus; TAS:ProtInc.
 GO:0042110; P:T cell activation; IEA:Compara.
 GO:0045351; P:type I interferon biosynthetic process; IEA:Compara.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR016669; Interferon_alpha/beta_rcpt-1.
 IPR015373; Interferon_alpha/beta_rcpt_bsu. 

Pfam

 PF09294; Interfer-bind 

SMART

 SM00060; FN3 

PROSITE

 PS50853; FN3 

PRINTS