CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034210
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein diaphanous homolog 1 
Protein Synonyms/Alias
  
Gene Name
 Diap1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
459HELQVEMKKMENDFEubiquitination[1]
506KLTGEVAKLSKELEDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1220 AA 
Protein Sequence
MADELERFTS MRIKKEKEKP NSAHRNSSAS YGDDPTAQSL QDISDEQVLV LFEQMLVDMN 60
LNEEKQQPLR EKDIVIKREM VSQYLHTSKA GMNQKESSRS AMMYIQELRS GLRDMHLLSC 120
LESLRVSLNN NPVSWVQTFG AEGLASLLDI LKRLHDEKEE TSGNYDSRNQ HEIIRCLKAF 180
MNNKFGIKTM LETEEGILLL VRAMDPAVPN MMIDAAKLLS ALCILPQPED MNERVLEAMT 240
ERAEMDEVER FQPLLDGLKS GTSIALKVGC LQLINALITP AEELDFRVHI RSELMRLGLH 300
QVLQELREIE NEDMKVQLCV FDEQGDEDFF DLKGRLDDIR MEMDDFGEVF QIILNTVKDS 360
KAEPHFLSIL QHLLLVRNDY EARPQYYKLI EECVSQIVLH KNGTDPDFKC RHLQIDIERL 420
VDQMIDKTKV EKSEAKATEL EKKLDSELTA RHELQVEMKK MENDFEQKLQ DLQGEKDALD 480
SEKQQITAQK QDLEAEVSKL TGEVAKLSKE LEDAKNEMAS LSAVVVAPSV SSSAAVPPAP 540
PLPGDSGTVI PPPPPPPPLP GGVVPPSPPL PPGTCIPPPP PLPGGACIPP PPQLPGSAAI 600
PPPPPLPGVA SIPPPPPLPG ATAIPPPPPL PGATAIPPPP PLPGGTGIPP PPPPLPGSVG 660
VPPPPPLPGG PGLPPPPPPF PGAPGIPPPP PGMGVPPPPP FGFGVPAAPV LPFGLTPKKV 720
YKPEVQLRRP NWSKFVAEDL SQDCFWTKVK EDRFENNELF AKLTLAFSAQ TKTSLAKKDQ 780
EGGEEKKSVQ KKKVKELKVL DSKTAQNLSI FLGSFRMPYQ EIKNVILEVN EAVLTESMIQ 840
NLIKQMPEPE QLKMLSELKE EYDDLAESEQ FGVVMGTVPR LRPRLNAILF KLQFSEQVEN 900
IKPEIVSVTA ACEELRKSEN FSSLLELTLL VGNYMNAGSR NAGAFGFNIS FLCKLRDTKS 960
ADQKMTLLHF LAELCENDHP EVLKFPDELA HVEKASRVSA ENLQKSLDQM KKQIADVERD 1020
VQNFPAATDE KDKFVEKMTS FVKDAQEQYN KLRMMHSNME TLYKELGDYF VFDPKKLSVE 1080
EFFMDLHNFR NMFLQAVKEN QKRRETEEKM RRAKLAKEKA EKERLEKQQK REQLIDMNAE 1140
GDETGVMDSL LEALQSGAAF RRKRGPRQVN RKAGCAVTSL LASELTKDDA MAPGPVKVPK 1200
KSEGVPTILE EAKELVGRAS 1220 
Gene Ontology
 GO:0032587; C:ruffle membrane; IDA:MGI.
 GO:0003779; F:actin binding; IDA:MGI.
 GO:0005522; F:profilin binding; IDA:MGI.
 GO:0017048; F:Rho GTPase binding; IDA:MGI.
 GO:0030041; P:actin filament polymerization; IDA:MGI. 
Interpro
 IPR003104; Actin-bd_FH2/DRF_autoreg.
 IPR016024; ARM-type_fold.
 IPR014767; Diaphanous_autoregulatory.
 IPR010465; Drf_DAD.
 IPR010472; Drf_FH3.
 IPR010473; Drf_GTPase-bd.
 IPR015425; FH2_actin-bd.
 IPR009408; Formin_homology_1.
 IPR014768; GTPase-bd/formin_homology_3. 
Pfam
 PF06345; Drf_DAD
 PF06346; Drf_FH1
 PF06367; Drf_FH3
 PF06371; Drf_GBD
 PF02181; FH2 
SMART
 SM00498; FH2 
PROSITE
 PS51231; DAD
 PS51444; FH2
 PS51232; GBD_FH3 
PRINTS