UniProt Accession

 BNIP2_HUMAN; Q12982; B4DS94 

Genbank Protein ID

 U15173; AK299628; AY268590; AC092755; BC002461 

Genbank Nucleotide ID

 AAC00021.1; BAG61556.1; AAP03429.1; AAH02461.1 

Protein Name

 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 

Protein Synonyms/Alias

  

Gene Name

 BNIP2 

Gene Synonyms/Alias

 NIP2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
267	TRPFISSKFSQKIRY	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. 

Sequence Annotation

 DOMAIN 147 304 CRAL-TRIO.
 MOD_RES 114 114 Phosphoserine.  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 314 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005635; C:nuclear envelope; IDA:UniProtKB.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; TAS:UniProtKB.
 GO:0005096; F:GTPase activator activity; TAS:ProtInc.
 GO:0006915; P:apoptotic process; IPI:MGI.
 GO:0042692; P:muscle cell differentiation; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.
 GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome. 

Interpro

 IPR022181; Bcl2-/adenovirus-E1B.
 IPR001251; CRAL-TRIO_dom. 

Pfam

 PF12496; BNIP2 

SMART

 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO 

PRINTS