CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023999
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gap junction alpha-3 protein 
Protein Synonyms/Alias
 Connexin-46; Cx46 
Gene Name
 GJA3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
123KRESPSPKEPPQDNPubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. 
Sequence Annotation
  
Keyword
 Cataract; Cell junction; Cell membrane; Complete proteome; Disease mutation; Gap junction; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 435 AA 
Protein Sequence
MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEDVWGDEQS DFTCNTQQPG 60
CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV RMEEKKKERE EEEQLKRESP 120
SPKEPPQDNP SSRDDRGRVR MAGALLRTYV FNIIFKTLFE VGFIAGQYFL YGFELKPLYR 180
CDRWPCPNTV DCFISRPTEK TIFIIFMLAV ACASLLLNML EIYHLGWKKL KQGVTSRLGP 240
DASEAPLGTA DPPPLPPSSR PPAVAIGFPP YYAHTAAPLG QARAVGYPGA PPPAADFKLL 300
ALTEARGKGQ SAKLYNGHHH LLMTEQNWAN QAAERQPPAL KAYPAASTPA APSPVGSSSP 360
PLAHEAEAGA APLLLDGSGS SLEGSALAGT PEEEEQAVTT AAQMHQPPLP LGDPGRASKA 420
SRASSGRARP EDLAI 435 
Gene Ontology
 GO:0005922; C:connexon complex; IEA:InterPro.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005243; F:gap junction channel activity; IEA:InterPro.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0006810; P:transport; NAS:ProtInc.
 GO:0007601; P:visual perception; TAS:ProtInc. 
Interpro
 IPR000500; Connexin.
 IPR002262; Connexin46.
 IPR019570; Connexin_CCC.
 IPR017990; Connexin_CS.
 IPR013092; Connexin_N. 
Pfam
 PF00029; Connexin
 PF10582; Connexin_CCC 
SMART
 SM00037; CNX
 SM01089; Connexin_CCC 
PROSITE
 PS00407; CONNEXINS_1
 PS00408; CONNEXINS_2 
PRINTS
 PR00206; CONNEXIN.
 PR01133; CONNEXINA3.