CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016630
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucuronosyltransferase 2A3 
Protein Synonyms/Alias
 UDPGT 2A3 
Gene Name
 Ugt2a3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
57GHEVTVLKYPSIIIDubiquitination[1]
135RSVLYNQKFMDKLRDacetylation[2, 3]
135RSVLYNQKFMDKLRDsuccinylation[2]
135RSVLYNQKFMDKLRDubiquitination[1]
252TFCKTVGKADIWLIRubiquitination[1]
342VLWRYSGKKPATLGSacetylation[4]
367NDLLGHPKTKAFITHubiquitination[1]
439VINEPSYKENAMRLSubiquitination[1]
455IHHDQPVKPLDRAVFacetylation[4]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). 
Sequence Annotation
 CARBOHYD 102 102 N-linked (GlcNAc...) (Potential).
 CARBOHYD 204 204 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 534 AA 
Protein Sequence
MVSEKCVAAF FLLQLCWAGC GFCSKVLVWP CDMSHWLNLK TILEELGARG HEVTVLKYPS 60
IIIDQSKRIP LHFENIPLLY EIETAENRLN EIANLAVNVI PNLSLWEAAK TLQDFFLQVT 120
GDFESICRSV LYNQKFMDKL RDAQYDVVVI DPVVPCGELV AEVLQIPFVY TLRFSMGYYM 180
EKHCGQLPIP LSYVPVVMSE LTDNMTFTER VKNMMFSLLF EYWLQQYDFA FWDQFYSETL 240
GRPTTFCKTV GKADIWLIRT YWDVEFPRPY LPNFEFVGGL HCKPAKPLPK EMEEFVQSSG 300
EHGVVVFSLG SMVKNLTEEK ANLIASVLAQ IPQKVLWRYS GKKPATLGSN TRLFNWIPQN 360
DLLGHPKTKA FITHGGTNGI YEAIYHGVPM VGVPMLGDQP HNIAHMEAKG AALKVSISTM 420
TSTDLLSAVR AVINEPSYKE NAMRLSRIHH DQPVKPLDRA VFWIEFVMRH KGAKHLRVAA 480
HDLSWFQYHS LDVIGFLLLC VVTLTFIITK FCLFVCQKLY MKESKKMGNR KKKN 534 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015020; F:glucuronosyltransferase activity; IEA:EC.
 GO:0052695; P:cellular glucuronidation; IEA:Compara. 
Interpro
 IPR002213; UDP_glucos_trans. 
Pfam
 PF00201; UDPGT 
SMART
  
PROSITE
 PS00375; UDPGT 
PRINTS