CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040091
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prohibitin-2 
Protein Synonyms/Alias
  
Gene Name
 Phb2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
26DIRARPRKISSPTGSacetylation[1, 2]
26DIRARPRKISSPTGSsuccinylation[2]
34ISSPTGSKDLQMVNIacetylation[3]
84VLKSVVAKFNASQLIacetylation[1, 3]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 104 AA 
Protein Sequence
LAEGLHFRIP WFQYPIIYDI RARPRKISSP TGSKDLQMVN ISLRVLSRPN AQELPSMYQR 60
LGLDYEERVL PSIVNEVLKS VVAKFNASQL ITQRAQFSDP LKPS 104 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0060749; P:mammary gland alveolus development; IMP:MGI.
 GO:0060744; P:mammary gland branching involved in thelarche; IMP:MGI.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IMP:MGI.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IMP:MGI. 
Interpro
 IPR001107; Band_7.
 IPR000163; Prohibitin. 
Pfam
 PF01145; Band_7 
SMART
 SM00244; PHB 
PROSITE
  
PRINTS
 PR00679; PROHIBITIN.