CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024964
UniProt Accession
Genbank Protein ID
 L08961 
Genbank Nucleotide ID
Protein Name
 Tyrosine kinase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
546VLRLQLEKLLESLPDubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 Kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 600 AA 
Protein Sequence
MKPITKQQGE LVGSRISHVW QSAGISKELL EEVGQNGSRA RISVQVHNAT CTVRIAAVTK 60
GGVGPFSDPV CKYYTGGNTG YFCANVSRMS THRSFKLNNT LHIPCRGRPQ PNVTCRDLKR 120
CNVSDEVQRG MPGNVTPCTR LGRLCPLFNS GAWQRRSCAH HLWLLLWIIL IGLVLYISLA 180
IRKRVQETKF GNAFTEEDSE LVVNYIAKKS FCRRAIELTH SLGVSEELQN KLEDVVIDRN 240
LLILGKILGE GEKGTVYEGL WNIPEGKEVK IPVAIKTLKL DTMANKEILD EASVMKGFGN 300
PHVVRLLGIC MTSTIYVITE YCLLVYRRNK DKAEQHRSNC AELNPPLQTL LKFMVDIALG 360
MEYLSNRNFL HRDLAARNCM LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE 420
SLADRVYTKS DVWAFGVTMW EIATTLRGMT PYPGVQNHEM YDYLLHGHRL KQPRTAWNCT 480
EIRIRLLKLP ILGSRTMRPM TIFSMATRLS SPKTAWMNCM KKCTLAGEPI PKTGPTFSVL 540
RLQLEKLLES LPDVRNQADV IYVNTQLLES EGLARVHPCS TGLEHHPCSE HRPRPHLYNC 600 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005524; F:ATP binding; NAS:UniProtKB.
 GO:0004713; F:protein tyrosine kinase activity; NAS:UniProtKB.
 GO:0007166; P:cell surface receptor signaling pathway; NAS:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
 SM00219; TyrKc 
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.