CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038687
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin-protein ligase E3A 
Protein Synonyms/Alias
  
Gene Name
 Ube3a 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28RMKRAAAKHLIERYYubiquitination[1]
69DNNAAAIKALELYKIubiquitination[1]
75IKALELYKINAKLCDubiquitination[1]
88CDPHPSKKGASSAYLubiquitination[1]
99SAYLENSKGASNNSEubiquitination[1]
118KKEGKDFKDVIYLTEubiquitination[1]
190KDEDEKEKAACSAAAubiquitination[1]
310LFCKAMCKLPLEAQGubiquitination[1]
318LPLEAQGKLIRLWSKubiquitination[1]
325KLIRLWSKYSADQIRubiquitination[1]
345FQQLITYKVISNEFNubiquitination[1]
368DAIVAASKCLKMVYYubiquitination[1]
416GDERRNKKGPRVDPLubiquitination[1]
430LETELGVKTLDCRKPubiquitination[1]
463DKDYTFFKVETENKFubiquitination[1]
547MENPADLKKQLYVEFubiquitination[1]
548ENPADLKKQLYVEFEubiquitination[1]
697DLKENGDKIPITNENubiquitination[1]
706PITNENRKEFVNLYSubiquitination[1]
719YSDYILNKSVEKQFKubiquitination[1]
817APVGGLGKLKMIIAKubiquitination[1]
819VGGLGKLKMIIAKNGubiquitination[1]
824KLKMIIAKNGPDTERubiquitination[1]
859KLKERLLKAITYAKGubiquitination[1]
865LKAITYAKGFGML**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 870 AA 
Protein Sequence
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNSEIKMN KKEGKDFKDV 120
IYLTEEKVYE IYEFCRESED YSPLIRVIGR IFSSAEALVL SFRKVKQHTK EELKSLQEKD 180
EDKDEDEKEK AACSAAAMEE DSEASSSRMG DSSQGDNNVQ KLGPDDVTVD IDAIRRVYSS 240
LLANEKLETA FLNALVYLSP NVECDLTYHN VYTRDPNYLN LFIIVMENSN LHSPEYLEMA 300
LPLFCKAMCK LPLEAQGKLI RLWSKYSADQ IRRMMETFQQ LITYKVISNE FNSRNLVNDD 360
DAIVAASKCL KMVYYANVVG GDVDTNHNEE DDEEPIPESS ELTLQELLGD ERRNKKGPRV 420
DPLETELGVK TLDCRKPLIS FEEFINEPLN DVLEMDKDYT FFKVETENKF SFMTCPFILN 480
AVTKNLGLYY DNRIRMYSER RITVLYSLVQ GQQLNPYLRL KVRRDHIIDD ALVRLEMIAM 540
ENPADLKKQL YVEFEGEQGV DEGGVSKEFF QLVVEEIFNP DIGMFTYDEA TKLFWFNPSS 600
FETEGQFTLI GIVLGLAIYN NCILDVHFPM VVYRKLMGKK GTFRDLGDSH PVLYQSLKDL 660
LEYEGSVEDD MMITFQISQT DLFGNPMMYD LKENGDKIPI TNENRKEFVN LYSDYILNKS 720
VEKQFKAFRR GFHMVTNESP LKYLFRPEEI ELLICGSRNL DFQALEETTE YDGGYTRESV 780
VIREFWEIVH SFTDEQKRLF LQFTTGTDRA PVGGLGKLKM IIAKNGPDTE RLPTSHTCFN 840
VLLLPEYSSK EKLKERLLKA ITYAKGFGML 870 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.
 GO:0030521; P:androgen receptor signaling pathway; IPI:MGI.
 GO:0001541; P:ovarian follicle development; IMP:MGI.
 GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0060736; P:prostate gland growth; IMP:MGI.
 GO:0070936; P:protein K48-linked ubiquitination; IEA:Compara.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
 GO:0035037; P:sperm entry; IMP:MGI. 
Interpro
 IPR000569; HECT.
 IPR017134; Ubiquitin-protein_ligase_E6-AP. 
Pfam
 PF00632; HECT 
SMART
 SM00119; HECTc 
PROSITE
 PS50237; HECT 
PRINTS