CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045397
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Deoxyhypusine synthase 
Protein Synonyms/Alias
  
Gene Name
 DHPS 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
33GEFSLRGKELRENGIubiquitination[1]
82GVKWTPSKMIARLGKubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 138 AA 
Protein Sequence
MVDVLVTTAG GVEEDLIKCL APTYLGEFSL RGKELRENGI NRIGNLLVPN ENYCKFEDWL 60
MPILDQMVME QNTEGVKWTP SKMIARLGKE INNPESVYYW AQKNHIPVFS PALTDGSLGD 120
MIFFHSYKNP GLVLDIVE 138 
Gene Ontology
 GO:0008612; P:peptidyl-lysine modification to hypusine; IEA:InterPro. 
Interpro
 IPR002773; Deoxyhypusine_synthase. 
Pfam
 PF01916; DS 
SMART
  
PROSITE
  
PRINTS