| Tag | Content |
|---|
| CPLM ID | CPLM-001674 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Claudin-1 |
Protein Synonyms/Alias | Senescence-associated epithelial membrane protein |
Gene Name | CLDN1 |
Gene Synonyms/Alias | CLD1; SEMP1; UNQ481/PRO944 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 208 | KPAPSSGKDYV**** | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). Acts as a co- receptor for HCV entry into hepatic cells. |
Sequence Annotation | REGION 210 211 Interactions with TJP1, TJP2, TJP3 and
MOD_RES 205 205 Phosphoserine (By similarity).
MOD_RES 206 206 Phosphoserine (By similarity). |
Keyword | Cell junction; Cell membrane; Complete proteome; Host-virus interaction; Ichthyosis; Membrane; Phosphoprotein; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 211 AA |
Protein Sequence | MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG 60
QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV 120
IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA 180
LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V 211 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:Compara. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0016328; C:lateral plasma membrane; IEA:Compara. GO:0005923; C:tight junction; ISS:UniProtKB. GO:0042802; F:identical protein binding; ISS:UniProtKB. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB. GO:0045216; P:cell-cell junction organization; IMP:MGI. GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |