CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000987
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Catenin delta-1 
Protein Synonyms/Alias
 Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas) 
Gene Name
 CTNND1 
Gene Synonyms/Alias
 KIAA0384 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
573GAKKGKGKKPIEDPAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. 
Sequence Annotation
 REPEAT 358 395 ARM 1.
 REPEAT 398 437 ARM 2.
 REPEAT 441 475 ARM 3.
 REPEAT 476 516 ARM 4.
 REPEAT 534 573 ARM 5.
 REPEAT 583 624 ARM 6.
 REPEAT 653 693 ARM 7.
 REPEAT 700 739 ARM 8.
 REPEAT 740 780 ARM 9.
 REPEAT 781 826 ARM 10.
 MOTIF 622 634 Nuclear localization signal (By
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 4 4 Phosphoserine.
 MOD_RES 47 47 Phosphoserine.
 MOD_RES 112 112 Phosphotyrosine; by FYN.
 MOD_RES 228 228 Phosphotyrosine (By similarity).
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 257 257 Phosphotyrosine (By similarity).
 MOD_RES 268 268 Phosphoserine.
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 288 288 Phosphoserine; by PAK7/PAK5.
 MOD_RES 291 291 Phosphotyrosine (By similarity).
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 346 346 Phosphoserine (By similarity).
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 811 811 Phosphoserine.
 MOD_RES 847 847 Phosphoserine.
 MOD_RES 857 857 Phosphoserine.
 MOD_RES 859 859 Phosphoserine.
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 865 865 Phosphotyrosine (By similarity).
 MOD_RES 879 879 Phosphoserine.
 MOD_RES 904 904 Phosphotyrosine (By similarity).
 MOD_RES 916 916 Phosphothreonine.
 MOD_RES 920 920 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative initiation; Alternative splicing; Cell adhesion; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 968 AA 
Protein Sequence
MANGTLTRRH QNGRFVGDAD LERQKFSDLK LNGPQDHSHL LYSTIPRMQE PGQIVETYTE 60
EDPEGAMSVV SVETSDDGTT RRTETTVKKV VKTVTTRTVQ PVAMGPDGLP VDASSVSNNY 120
IQTLGRDFRK NGNGGPGPYV GQAGTATLPR NFHYPPDGYS RHYEDGYPGG SDNYGSLSRV 180
TRIEERYRPS MEGYRAPSRQ DVYGPQPQVR VGGSSVDLHR FHPEPYGLED DQRSMGYDDL 240
DYGMMSDYGT ARRTGTPSDP RRRLRSYEDM IGEEVPSDQY YWAPLAQHER GSLASLDSLR 300
KGGPPPPNWR QPELPEVIAM LGFRLDAVKS NAAAYLQHLC YRNDKVKTDV RKLKGIPVLV 360
GLLDHPKKEV HLGACGALKN ISFGRDQDNK IAIKNCDGVP ALVRLLRKAR DMDLTEVITG 420
TLWNLSSHDS IKMEIVDHAL HALTDEVIIP HSGWEREPNE DCKPRHIEWE SVLTNTAGCL 480
RNVSSERSEA RRKLRECDGL VDALIFIVQA EIGQKDSDSK LVENCVCLLR NLSYQVHREI 540
PQAERYQEAA PNVANNTGPH AASCFGAKKG KGKKPIEDPA NDTVDFPKRT SPARGYELLF 600
QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIADLLT 660
NEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVISILN 720
TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 780
KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD KKPDREEIQM SNMGSNTKSL 840
DNNYSTPNER GDHNRTLDRS GDLGDMEPLK GTTPLMQDEG QESLEEELDV LVLDDEGGQV 900
SYPSMQKI 908 
Gene Ontology
 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005829; C:cytosol; IMP:BHF-UCL.
 GO:0030027; C:lamellipodium; IEA:Compara.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0034332; P:adherens junction organization; TAS:Reactome.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0016337; P:cell-cell adhesion; IEA:Compara.
 GO:0060690; P:epithelial cell differentiation involved in salivary gland development; IEA:Compara.
 GO:0030216; P:keratinocyte differentiation; IEA:Compara.
 GO:0001738; P:morphogenesis of a polarized epithelium; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007435; P:salivary gland morphogenesis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF00514; Arm 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS