UniProt Accession

 ESCO2_HUMAN; Q56NI9; B3KW59 

Genbank Protein ID

 AY882862; AK124215 

Genbank Nucleotide ID

 AAX68677.1; BAG54021.1 

Protein Name

 N-acetyltransferase ESCO2 

Protein Synonyms/Alias

 Establishment of cohesion 1 homolog 2; ECO1 homolog 2 

Gene Name

 ESCO2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	ESRSTCLKTNDEDKS	acetylation	[1]
237	LGRTQKSKSEVIEDS	ubiquitination	[2]
252	DVETVSEKKTFATRQ	ubiquitination	[2]
303	SKEHKVDKNEAFSSE	ubiquitination	[2]
498	CLIAEPIKQAFRVLS	ubiquitination	[3]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. 

Sequence Annotation

 ZN_FING 387 411 CCHH-type.
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 75 75 Phosphoserine.
 MOD_RES 244 244 Phosphoserine.  

Keyword

 Acyltransferase; Cell cycle; Chromosome; Complete proteome; Disease mutation; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 601 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016746; F:transferase activity, transferring acyl groups; IEA:UniProtKB-KW.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0034421; P:post-translational protein acetylation; IMP:UniProtKB.
 GO:0006275; P:regulation of DNA replication; IMP:UniProtKB. 

Interpro

 IPR026656; AcTrfase_ESCO. 

Pfam

  

SMART

  

PROSITE

  

PRINTS