CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044852
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 RNA polymerase II subunit A C-terminal domain phosphatase 
Protein Synonyms/Alias
  
Gene Name
 CTDP1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
69DLTQLQSKNGKQQVPubiquitination[1]
215ECIDPFSKTGNLRNLubiquitination[1, 2, 3]
251PNLITVKKYVYFQGTubiquitination[1]
546KYDRYLNKEIEEAPDubiquitination[1]
585PTNFPIEKTREHYHAubiquitination[1]
652SCLERWDKVEEQLFPubiquitination[1]
712IYDSNTGKLIRTGARacetylation[3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 799 AA 
Protein Sequence
ASGGCVRPAR PERRLRSERA GVVRELCAQP GQVVAPGAVL VRLEGCSHPV VMKGLCAECG 60
QDLTQLQSKN GKQQVPLSTA TVSMVHSVPE LMVSSEQAEQ LGREDQQRLH RNRKLVLMVD 120
LDQTLIHTTE QHCQQMSNKG IFHFQLGRGE PMLHTRLRPH CKDFLEKIAK LYELHVFTFG 180
SRLYAHTIAG FLDPEKKLFS HRILSRDECI DPFSKTGNLR NLFPCGDSMV CIIDDREDVW 240
KFAPNLITVK KYVYFQGTGD MNAPPGSRES QTRKKVNHSR GTEVSEPSPP VRDPEGVTQA 300
PGVEPSNGLE KPARELNGSE AATPRDSPRP GKPDERDIWP PAQAPTSSQE LAGAPEPQGS 360
CAQGGRVAPG QRPAQGATGT DLDFDLSSDS ESSSESEGTK SSSSASDGES EGKRGRQKPK 420
AAPEGAGALA QGSSLEPGRP AAPSLPGEAE PGAHAPDKEP ELGGQEEGER DGLCGLGNGC 480
ADRKEAETES QNSELSGVTA GESLDQSMEE EEEEDTDEDD HLIYLEEILV RVHTDYYAKY 540
DRYLNKEIEE APDIRKIVPE LKSKVLADVA IIFSGLHPTN FPIEKTREHY HATALGAKIL 600
TRLVLSPDAP DRATHLIAAR AGTEKVLQAQ ECGHLHVVNP DWLWSCLERW DKVEEQLFPL 660
RDDHTKAQRE NSPAAFPDRE GVPPTALFHP MPVLPKAQPG PEVRIYDSNT GKLIRTGARG 720
PPAPSSSLPI RQEPSSFRAV PPPQPQMFGE ELPDAQDGEQ PGPSRRKRQP SMSETMPLYT 780
LCKEDLESMD KERPQEEAE 799 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:InterPro. 
Interpro
 IPR001357; BRCT_dom.
 IPR015388; FCP1_C.
 IPR011947; FCP1_euk.
 IPR023214; HAD-like_dom.
 IPR004274; NIF. 
Pfam
 PF09309; FCP1_C
 PF03031; NIF
 PF12738; PTCB-BRCT 
SMART
 SM00292; BRCT
 SM00577; CPDc 
PROSITE
 PS50172; BRCT
 PS50969; FCP1 
PRINTS