UniProt Accession

 PTCD3_HUMAN; Q96EY7; A6NHD2; D6W5M1; Q597H0; Q658Y9; Q9BUZ8; Q9NWL0 

Genbank Protein ID

 AK000765; AC009309; CH471053; CH471053; BC001758; BC011832; AL832520; AY277598 

Genbank Nucleotide ID

 BAA91370.1; EAW99464.1; EAW99465.1; AAH01758.3; AAH11832.3; CAH56345.1; AAQ18037.1 

Protein Name

 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 

Protein Synonyms/Alias

 Transformation-related gene 15 protein; TRG-15 

Gene Name

 PTCD3 

Gene Synonyms/Alias

 TRG15 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	SGSATLSKVEGTDVT	ubiquitination	[1]
67	PKKKTWDKVAVLQAL	ubiquitination	[1, 2, 3]
126	FIINSYPKYFQKDIA	acetylation	[4]
126	FIINSYPKYFQKDIA	ubiquitination	[2, 3]
158	DISEAALKERIELRK	ubiquitination	[1]
387	DQPGDPLKRSSFIIY	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Mitochondrial RNA-binding protein that has a role in mitochondrial translation. 

Sequence Annotation

 REPEAT 149 183 PPR 1.
 REPEAT 184 219 PPR 2.
 REPEAT 255 289 PPR 3.
 REPEAT 290 330 PPR 4.
 REPEAT 331 367 PPR 5.
 REPEAT 368 409 PPR 6.
 REPEAT 412 446 PPR 7.
 REPEAT 454 488 PPR 8.
 REPEAT 489 523 PPR 9.
 REPEAT 572 606 PPR 10.
 MOD_RES 126 126 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Repeat; RNA-binding; rRNA-binding; Transit peptide; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 689 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0043024; F:ribosomal small subunit binding; IDA:UniProtKB.
 GO:0019843; F:rRNA binding; IDA:UniProtKB.
 GO:0032543; P:mitochondrial translation; IMP:UniProtKB.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 

Interpro

 IPR002885; Pentatricopeptide_repeat. 

Pfam

 PF13041; PPR_2
 PF13812; PPR_3 

SMART

  

PROSITE

 PS51375; PPR 

PRINTS