UniProt Accession

 RAN_RAT; P62828; P17080; P28746; P28747; Q9CSP3; Q9CWI7; Q9CZA2; Q9UDJ5; Q9UEU9 

Genbank Protein ID

 AF306457; BC059123 

Genbank Nucleotide ID

 AAG33229.1; AAH59123.1 

Protein Name

 GTP-binding nuclear protein Ran 

Protein Synonyms/Alias

 GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein 

Gene Name

 Ran 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
23	VGDGGTGKTTFVKRH	acetylation	[1]
28	TGKTTFVKRHLTGEF	acetylation	[1]
37	HLTGEFEKKYVATLG	acetylation	[1]
60	HTNRGPIKFNVWDTA	acetylation	[1]
71	WDTAGQEKFGGLRDG	ubiquitination	[2]
99	VTSRVTYKNVPNWHR	acetylation	[1]
134	KDRKVKAKSIVFHRK	acetylation	[1]
142	SIVFHRKKNLQYYDI	ubiquitination	[2]
152	QYYDISAKSNYNFEK	acetylation	[1]
159	KSNYNFEKPFLWLAR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (By similarity). 

Sequence Annotation

 NP_BIND 17 24 GTP (By similarity).
 NP_BIND 65 69 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 60 60 N6-acetyllysine (By similarity).
 MOD_RES 71 71 N6-acetyllysine; alternate (By
 MOD_RES 99 99 N6-acetyllysine (By similarity).
 MOD_RES 159 159 N6-acetyllysine (By similarity).
 CROSSLNK 71 71 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Isopeptide bond; Mitosis; Nucleotide-binding; Nucleus; Protein transport; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 216 AA 

Protein Sequence

Gene Ontology

 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0006913; P:nucleocytoplasmic transport; IEA:InterPro.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR002041; Ran_GTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase. 

Pfam

 PF00071; Ras 

SMART

 SM00176; RAN 

PROSITE

 PS51418; RAN 

PRINTS

 PR00627; GTPRANTC4.