CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028560
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MutS protein homolog 5 
Protein Synonyms/Alias
 cDNA FLJ39914 fis, clone SPLEN2018732, highly similar to MutS protein homolog 5 
Gene Name
 MSH5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158HYRSARTKELDALLGubiquitination[1]
258STECGGDKGRVKVITubiquitination[1, 2]
262GGDKGRVKVITGPNSubiquitination[1, 2]
272TGPNSSGKSIYLKQVubiquitination[1]
446DKLVARGKEVSDLIRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MWPVLLFVFL SQTVYSALGL RDACRSLPQS IQLFRDIAQE FSDDLHHIAS LIGKVVDFEG 60
SLAENRFTVL PNIDPEIDEK KRRLMGLPSF LTEVARKELE NLDSRIPSCS VIYIPLIGFL 120
LSIPRLPSMV EASDFEINGL DFMFLSEEKL HYRSARTKEL DALLGDLHCE IRDQETLLMY 180
QLQCQVLARA AVLTRVLDLA SRLDVLLALA SAARDYGYSR PRYSPQVLGV RIQNGRHPLM 240
ELCARTFVPN STECGGDKGR VKVITGPNSS GKSIYLKQVG LITFMALVGS FVPAEEAEIG 300
AVDAIFTRIH SCESISLGLS TFMIDLNQVA KAVNNATAQS LVLIDEFGKG TNTVDGLALL 360
AAVLRHWLAR GPTCPHIFVA TNFLSLVQLQ LLPQGPLVQY LTMETCEDGN DLVFFYQVCE 420
GVAKASHASH TAAQAGLPDK LVARGKEVSD LIRSGKPIKP VKDLLKKNQM ENCQTLVDKF 480
MKLDLEDPNL DLNVFMSQEV LPAATSIL 508 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0030983; F:mismatched DNA binding; IEA:InterPro.
 GO:0006298; P:mismatch repair; IEA:InterPro. 
Interpro
 IPR000432; DNA_mismatch_repair_MutS_C.
 IPR007861; DNA_mismatch_repair_MutS_clamp.
 IPR007696; DNA_mismatch_repair_MutS_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF05192; MutS_III
 PF05190; MutS_IV
 PF00488; MutS_V 
SMART
 SM00534; MUTSac
 SM00533; MUTSd 
PROSITE
 PS00486; DNA_MISMATCH_REPAIR_2 
PRINTS