CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022759
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-acetyltransferase 6 
Protein Synonyms/Alias
 Protein fusion-2; Protein fus-2 
Gene Name
 Nat6 
Gene Synonyms/Alias
 Fus2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
242TVLRAFSKPPCPQPPacetylation[1, 2, 3]
303ETCYRDLKGCPIFWMacetylation[1, 3, 4, 5]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
 Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor (By similarity). 
Sequence Annotation
 DOMAIN 90 243 N-acetyltransferase.
 MOD_RES 233 233 Phosphoserine.  
Keyword
 Acyltransferase; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Transferase; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MELILSTSPA KLTLDPARQP ELTLRFNLSK LTLDPARQPE LSLSPRLAEL TLDPTCHPEM 60
SLSPGPAELT LDPQHQAKEL PVPKLPELIL EPVHCRPELM SACADLINDQ WPRSRASRLH 120
SLGQSSDAFP LCLMLLSPQP TPGAAPVVVG HARLSRVLDQ PHSLLVETVV VARPLRGRGF 180
GRRLMEGLEA FARARGFRRL HLTTHDQLYF YAHLGYQLGE PVQGLAFTNR RLSTTVLRAF 240
SKPPCPQPPC KEPILAAQAV PRSSKGPPLP PPPPLPQSLT ASPPPSPEPL PQSPLETCYR 300
DLKGCPIFWM EKDI 314 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0008080; F:N-acetyltransferase activity; IEA:InterPro. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR000182; GNAT_dom. 
Pfam
 PF00583; Acetyltransf_1 
SMART
  
PROSITE
 PS51186; GNAT 
PRINTS