| Tag | Content |
|---|
| CPLM ID | CPLM-024533 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Inter alpha-trypsin inhibitor, heavy chain 4 |
Protein Synonyms/Alias | ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4 |
Gene Name | Itih4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 103 | KEKAEAQKQYSAAVG | ubiquitination | [1] | | 224 | PTLSQQQKSQSEQDT | ubiquitination | [1] | | 336 | ATEENLNKAVNYASR | ubiquitination | [1] | | 607 | EQFQVAEKPVEVGDG | ubiquitination | [1] | | 641 | SKLMTVLKGSRSQIP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. |
Sequence Annotation | DOMAIN 29 148 VIT.
DOMAIN 274 457 VWFA.
CARBOHYD 81 81 N-linked (GlcNAc...).
CARBOHYD 517 517 N-linked (GlcNAc...).
CARBOHYD 577 577 N-linked (GlcNAc...).
CARBOHYD 874 874 N-linked (GlcNAc...).
DISULFID 761 937 By similarity. |
Keyword | Acute phase; Alternative splicing; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome; Secreted; Serine protease inhibitor; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 942 AA |
Protein Sequence | MKSPAPAHMW NLVLFLPSLL AVLPTTTAEK NGIDIYSLTV DSRVSSRFAH TVVTSRVVNR 60
ADAVQEATFQ VELPRKAFIT NFSMIIDGVT YPGVVKEKAE AQKQYSAAVG RGESAGIVKT 120
TGRQTEKFEV SVNVAPGSKI TFELIYQELL QRRLGMYELL LKVRPQQLVK HLQMDIYIFE 180
PQGISILETE STFMTPELAN ALTTSQNKTK AHIRFKPTLS QQQKSQSEQD TVLNGDFIVR 240
YDVNRSDSGG SIQIEEGYFV HHFAPENLPT MSKNVIFVID KSGSMSGKKI QQTREALVKI 300
LKDLSPQDQF NLIEFSGEAN QWKQSLVQAT EENLNKAVNY ASRIRAHGGT NINNAVLLAV 360
ELLDRSNQAE LLPSKSVSLI ILLTDGDPTV GETNPTIIQN NVREAINGQY SLFCLGFGFD 420
VNYPFLEKMA LDNGGLARRI YEDSDSALQL QDFYHEVANP LLSSVAFEYP SDAVEEVTRY 480
KFQHHFKGSE MVVAGKLQDQ GPDVLLAKVS GQMHMQNITF QTEASVAQQE KEFKSPKYIF 540
HNFMERLWAL LTIQQQLEQR ISASGAELEA LEAQVLNLSL KYNFVTPLTH MVVTKPEGQE 600
QFQVAEKPVE VGDGMQRLPL AAQAHPFRPP VRGSKLMTVL KGSRSQIPRL GDAVRASRQY 660
IPPGFPGPPG PPGFPAPPGP PGFPAPPGPP LASGSDFSLQ PSYERMLSLP SVAAQYPADP 720
HLVVTEKSKE STIPEESPNP DHPQVPTITL PLPGSSVDQL CVDILHSEKP MKLFVDPSQG 780
LEVTGKYENT GFSWLEVTIQ KPHLQVHATP ERLVVTRGRK NTEYKWKKTL FSVLPGLKMT 840
MNMMGLLQLS GPDKVTIGLL SLDDPQRGLM LLLNDTQHFS NNVKGELGQF YRDIVWEPPV 900
EPDNTKRTVK VQGVDYLATR ELKLSYQEGF PGAEISCWTV EI 942 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:MGI. GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:MGI. GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW. GO:0006953; P:acute-phase response; IEA:UniProtKB-KW. GO:0030212; P:hyaluronan metabolic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |