UniProt Accession

 CENPH_MOUSE; Q9QYM8; Q8R3K9; Q9D079; Q9D0N1 

Genbank Protein ID

 AB017634; AK011264; AK011738; BC025084 

Genbank Nucleotide ID

 BAA88520.1; BAB27505.1; BAB27810.1; AAH25084.1 

Protein Name

 Centromere protein H 

Protein Synonyms/Alias

 CENP-H 

Gene Name

 Cenph 

Gene Synonyms/Alias

 Enp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
147	ESSELEKKLLDVRKK	acetylation	[1]
153	KKLLDVRKKRLQLKQ	acetylation	[1]

Reference

 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Centromere; Chromosome; Coiled coil; Complete proteome; Kinetochore; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0000776; C:kinetochore; IDA:MGI.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043515; F:kinetochore binding; IDA:UniProtKB.
 GO:0051301; P:cell division; IEA:InterPro.
 GO:0007059; P:chromosome segregation; ISA:MGI.
 GO:0051383; P:kinetochore organization; TAS:UniProtKB.
 GO:0007067; P:mitosis; ISA:MGI. 

Interpro

 IPR008426; Centromere_CenpH. 

Pfam

 PF05837; CENP-H 

SMART

  

PROSITE

  

PRINTS