| Tag | Content |
|---|
| CPLM ID | CPLM-024758 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/threonine-protein kinase 10 |
Protein Synonyms/Alias | |
Gene Name | Stk10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 248 | NPMRVLLKIAKSDPP | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo (By similarity). |
Sequence Annotation | DOMAIN 36 294 Protein kinase.
NP_BIND 42 50 ATP (By similarity).
REGION 175 224 Activation segment (By similarity).
ACT_SITE 157 157 Proton acceptor (By similarity).
BINDING 65 65 ATP (By similarity).
BINDING 111 111 Inhibitor (By similarity).
BINDING 113 113 Inhibitor (By similarity).
BINDING 117 117 Inhibitor; via amide nitrogen (By
BINDING 175 175 Inhibitor (By similarity).
MOD_RES 13 13 Phosphoserine (By similarity).
MOD_RES 185 185 Phosphothreonine; by autocatalysis (By
MOD_RES 191 191 Phosphoserine; by autocatalysis (By
MOD_RES 438 438 Phosphoserine (By similarity).
MOD_RES 454 454 Phosphoserine (By similarity).
MOD_RES 549 549 Phosphoserine (By similarity).
MOD_RES 951 951 Phosphothreonine (By similarity). |
Keyword | ATP-binding; Cell cycle; Cell membrane; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 967 AA |
Protein Sequence | MAFANFRRIL RLSTFEKRKS REYEHVRRDL DPNDVWEILG ELGDGAFGKV YKAKNKETGA 60
LAAAKVIETK SEEELEDYIV EIEILATCDH PYIVKLLGAY YYDGKLWIMI EFCPGGAVDA 120
IMLELDRGLT EPQIQVVCRQ MLEALNFLHG KRIIHRDLKA GNVLMTLEGD IRLADFGVSA 180
KNLKTLQKRD SFIGTPYWMA PEVVLCETMK DAPYDYKADI WSLGITLIEM AQIEPPHHEL 240
NPMRVLLKIA KSDPPTLLTP SKWSTEFRDF LKIALDKNPE TRPSAAQLLQ HPFVSTVTSN 300
KALRELVAEA KAEVMEEIED GKEDGSEKDA VSAVPPPVNH TQDSSANGTQ PSLNSDKLLQ 360
DSSTPLPPSQ PQEPVNGPCN QPSGDGSPQN TSPADEVSKN DNGLKVPVPL RKSRPLSVDA 420
RIQVTEEKQI TDQAENPSSA ASKPPKVNQS RPNSSALETL GVETLANGGL ELPGSVTPNH 480
SKRASDCSNL STSESMDYGT SLSADLSLNK ETGSLSLKGS KLHNKTLKRT RRFVVDGVEV 540
SITTSKIISE DEKKDEEMRF LRRQELRELR LLQKEEHRNQ TQLSTKHELQ LEQMHRRFEQ 600
EINAKKKFYD VELENLERQQ KQQVEKMEQD HSVRRREEAK RIRLEQDRDY ARFQEQLKQM 660
KKEVKRSIEK ALRKQRQESM RMGQDSHTQK KQRLDRDFVA KQKEDLELAM KKLTAENRRE 720
ICDKERDCLN KKQELLRDRE AALWEMEEHQ LQERHQLVKQ QLKDQYFLQR HDLLRKHEKE 780
REQMQRYNQR MMEQLKVRQQ QEKARLPKIQ RSDGKTRMAM YKKSLHINGA GSASEQREKV 840
KQFSQQEEKR QKAERLQQQQ KHENQMRDMV AQCESNMNEL QQLQNEKCHL LVEHETQKLK 900
ALDESHNQSL KEWRDKLRPR KKALEEDLNQ KKREQEMFFR LSEEAETRPT TPNRASKFFP 960
YSSGDAS 967 |
Gene Ontology | GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |