CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007877
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box protein DAS1 
Protein Synonyms/Alias
 DST1-delta 6-azauracil sensitivity protein 1 
Gene Name
 DAS1 
Gene Synonyms/Alias
 YJL149W; J0634 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
640GWSKESNKNLENDSNubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). 
Sequence Annotation
 DOMAIN 46 91 F-box.  
Keyword
 Complete proteome; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 663 AA 
Protein Sequence
MPFQDYFQKK KAAFINRNNK SNADASALRD INDININFAA KSKNYVFPLT KLPDELMQEV 60
FSHLPQPDRL QLCLVNKRLN KIATKLLYRR IYLNDSNVVK SDFMHLAINW TLLNLPSSLK 120
EEESRDIANC KLKKLIETLQ NNIHITEVIQ WIRINWDLDS TLQRSILSIL CNQGKSLQRL 180
ENVTDPACND IISNGHFSRS NVSSFDMAPP NSLPEMVVPE NYIPNLTKYL SQRISSRLSH 240
MTLFIDPLKL FNYLYPLDIK LQIIDLKLHW RREFYNNDYF VKKIRPGNPL TKLSEVFDKR 300
TLKILTIISW NDTLLKRETE MLKDFKEFEN LEDLSLISIK QDVHILVDLF SSLTNLKRLK 360
MDFLEEYVPE PTNPHIFLSI LLACSKLQFI DLRYDGLIPQ IINIQENKFQ LNQQCNCTNC 420
QIVFSDILKG KIFMFPEDYY IHDLQDIAAK DIFKMMKYLS LLPYSKACDA YPSVRTQPMN 480
LTNFVTKMNR NLLEYRNSKS QLVPKIVNNP HQHSTVTSTS TAHMSEPEMI IIDDDDDDDE 540
INAAIPPSSD DTAATISTDL ELPHESLTKR DIIMCYHALI HHFKSIYVTF LKSFPHLRFL 600
MLNDIPTIVM EENNERIFEP VFYHYDYKSN LYGWSKESNK NLENDSNNNN NNSDTIARIA 660
TVM 663 
Gene Ontology
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:SGD.
 GO:0030674; F:protein binding, bridging; ISA:SGD.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISA:SGD. 
Interpro
 IPR001810; F-box_dom_cyclin-like. 
Pfam
 PF00646; F-box 
SMART
 SM00256; FBOX 
PROSITE
 PS50181; FBOX 
PRINTS