CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031686
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tripartite motif-containing protein 66 
Protein Synonyms/Alias
  
Gene Name
 TRIM66 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49PFFPRAQKGSPGVNGubiquitination[1]
129SSLQTSAKQIEDRIFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1245 AA 
Protein Sequence
MARNCSECKE KRAAHILCTY CNRWLCSSCT EEHRHSPVPG GPFFPRAQKG SPGVNGGPGD 60
FTLYCPLHTQ EVLKLFCETC DMLTCHSCLV VEHKEHRHVE EVLQNQRMLL EGVTTQVAHK 120
KSSLQTSAKQ IEDRIFEVKH QHRKVENQIK MAKMVLMNEL NKQANGLIEE LEGITNERKR 180
KLEQQLQSIM VLNRQFEHVQ NFINWAVCSK TSVPFLFSKE LIVFQMQRLL ETSCNTDPGS 240
PWSIRFTWEP NFWTKQLASL GCITTEGGQM SRADAPAYGG LQGSSPFYQS HQSPVAQQEA 300
LSHPSHKFQS PAVCSSSVCC SHCSPVSPSL KGQVPPPSIH PAHSFRQPPE MVPQQLGSLQ 360
CSALLPREKE LACSPHPPKL LQPWLETQPP VEQESTSQRL GQQLTSQPVC IVPPQDVQQG 420
AHAQPTLQTP SIQVQFGHHQ KLKLSHFQQQ PQQQLPPPPP PLPHPPPPLP PPPQQPHPPL 480
PPSQHLASSQ HESPPGPACS QNMDIMHHKF ELEEMQKDLE LLLQAQQPSL QLSQTKSPQH 540
LQQTIVGQIN YIVRQPAPVQ SQSQEETLQA TDEPPASQGS KPALPLDKNT AAALPQASGE 600
ETPLSVPPVD STIQHSSPNV VRKHSTSLSI MGFSNTLEME LSSTRLERPL EPQIQSVSNL 660
TAGAPQAVPS LLSAPPKMVS SLTSVQNQAM PSLTTSHLQT VPSLVHSTFQ SMPNLISDSP 720
QAMASLASDH PQAGPSLMSG HTQAVPSLAT CPLQSIPPVS DMQPETGSSS SSGRTSGSLC 780
PRDGADPSLE NALCKMESED STRFTDLLGQ GPIVPGLDAP KDLAIPSELE EPINLSVKKP 840
PLAPVVSTST ALQQYQNPKE CENFEQGALE LDAKENQSIR AFNSEHKIPY VRLERLKICA 900
ASSGEMPVFK LKPQKNDQDG SFLLIIECGT ESSSMSIKVS QDRLSEATQA PGLEGRKVTV 960
TSLAGQRPPE VEGTSPEEHR LIPRTPGAKK GPPAPIENED FCAVCLNGGE LLCCDRCPKV 1020
FHLSCHVPAL LSFPGGEWVC TLCRSLTQPE MEYDCENACY NQPGMRASPG LSMYDQKKCE 1080
KLVLSLCCNN LSLPFHEPVS PLARHYYQII KRPMDLSIIR RKLQKKDPAH YTTPEEVVSD 1140
VRLMFWNCAK FNYPDSEVAE AGRCLEVFFE GWLKEIYPEK RFAQPRQEDS DSEEVSSESG 1200
CSTPQGFPWP PYMQEGIQPK RRRRHMENER AKRMSFRLAN SISQV 1245 
Gene Ontology
 GO:0016235; C:aggresome; IDA:HPA.
 GO:0010369; C:chromocenter; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara. 
Interpro
 IPR003649; Bbox_C.
 IPR001487; Bromodomain.
 IPR019786; Zinc_finger_PHD-type_CS.
 IPR000315; Znf_B-box.
 IPR011011; Znf_FYVE_PHD.
 IPR001965; Znf_PHD.
 IPR019787; Znf_PHD-finger.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00439; Bromodomain
 PF00628; PHD
 PF00643; zf-B_box 
SMART
 SM00502; BBC
 SM00336; BBOX
 SM00297; BROMO
 SM00249; PHD 
PROSITE
 PS50014; BROMODOMAIN_2
 PS50119; ZF_BBOX
 PS01359; ZF_PHD_1
 PS50016; ZF_PHD_2 
PRINTS