| Tag | Content |
|---|
| CPLM ID | CPLM-013844 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein SMG7 |
Protein Synonyms/Alias | EST1-like protein C; SMG-7 homolog |
Gene Name | Smg7 |
Gene Synonyms/Alias | Est1c; Kiaa0250 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 776 | LGKIMPVKQSYYLQT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity). |
Sequence Annotation | REPEAT 152 185 TPR 1.
REPEAT 187 219 TPR 2.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 519 519 Phosphoserine (By similarity).
MOD_RES 732 732 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1138 AA |
Protein Sequence | MRTENLKSEE HLKSSNIRQA EVLKAEMTDS KLGPAEVWTS RQALQDLYQK MLVTDLEYAL 60
DKKVEQDLWN HAFKNQITTL QGQAKNRANP NRSEVQANLS LFLEAASGFY TQLLQELCTV 120
FNVDLPCRVK SSQLGIISNK QTHSSTIVKP QSSSCSYICQ HCLVHLGDIA RYRNQTSQAE 180
SYYRHAAQLV PSNGQPYNQL AILASSKGDH LTTIFYYCRS IAVKFPFPAA STNLQKALSK 240
ALESRDELKT KWGVSDFIKA FIKFHGHVYL SKSLEKLSPL REKLEEQFKR LLFQKAFNSQ 300
QLVHVTVINL FQLHHLRDFS NETEQHSYSQ DEQLCWTQLL ALFMSFLGIL CKCPLQNDSQ 360
ESNNAYPLPA VKVSMDWLRL RPRVFQEAVV DERQYIWPWL ISLLNSFHPR EDDLSNTNAT 420
PLPEEFELQG FLALRPSFRN LDFSKGHQGI TGDKEGQQRR IRQQRLISIG KWIADNQPRL 480
IQCENEVGKL LFITEIPELI LEDPSEAKEN LILQETSVVE SLATDGSPGL KSVLSTGRNP 540
SNSCDSGEKP VVTFKENIKP REVNQGRSFP PKEVKSQTEL RKTPVSEARK TPVTQTPSQT 600
SNSQFIPIHH PGAFPPLPSR PGFPPPTYVI PPPVAFSMGS GYTFPAGVSV PGTFLQSTAH 660
SPAGNQVQAG KQSHIPYSQQ RPSGPGPMNQ GPQQSQPPSQ PPLTSLPAQP TAQSTSQLQV 720
QALAQQQQSP TKVIPALGKS PPHHSGFQQY QQADASKQLW NPPQVQSPLG KIMPVKQSYY 780
LQTQDPIKLF EPSLQPPVIQ QQPLEKKMKP FPMEPYNHNP SEVKVPEFYW DSSYSMADNR 840
AVMAQQPNMD RRSKRSPGVF RPEQDPVPRM PFEDPKSSPL LPPDLLKSLA ALEEEEELIF 900
SNPPDLYPAL LGPLASLPGR SLFKSLLEKP SELMSHSSSF LSLTGFSVNQ ERYPNSSMFN 960
EVYGKNLTTS SKAELNPSVA SQETSLYSLF EGTPWSPSLP ASSDHSTPAS QSPHSSNPSS 1020
LPSSPPTHNH NSAPFSNFGP IGTPDNRDRR PADRWKTDKP AMGGFGVDYL SATSSSESSW 1080
HQASTPSGTW TGHGPSMEDS SAVLMESLKS IWSSSMMHPG PSALEQLLMQ QKQKQQRGQG 1140
AMNPPH 1146 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:HGNC. GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara. GO:0005634; C:nucleus; ISS:HGNC. GO:0051721; F:protein phosphatase 2A binding; ISS:HGNC. GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |