UniProt Accession

 TMX4_HUMAN; Q9H1E5; Q8N4P7; Q8NCC1; Q9UJA1; Q9ULQ8 

Genbank Protein ID

 AY359004; AK074838; AK075404; AL021396; BC033787; AL118494; AB032988 

Genbank Nucleotide ID

 AAQ89363.1; BAC11237.1; BAC11599.1; CAC17521.1; AAH33787.1; CAB56344.1; BAA86476.1 

Protein Name

 Thioredoxin-related transmembrane protein 4 

Protein Synonyms/Alias

 Thioredoxin domain-containing protein 13 

Gene Name

 TMX4 

Gene Synonyms/Alias

 KIAA1162; TXNDC13; PSEC0095; UNQ475/PRO938 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
90	ILQISVGKVDVIQEP	ubiquitination	[1]
115	LPAFFHAKDGIFRRY	ubiquitination	[1, 2]
138	LQNYILEKKWQSVEP	ubiquitination	[1, 3]
139	QNYILEKKWQSVEPL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 DOMAIN 30 137 Thioredoxin.
 MOD_RES 251 251 Phosphoserine.
 MOD_RES 259 259 Phosphoserine.
 DISULFID 64 67 Redox-active (Potential).  

Keyword

 Complete proteome; Disulfide bond; Electron transport; Membrane; Phosphoprotein; Polymorphism; Redox-active center; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS