UniProt Accession

 TRIA1_HUMAN; O43715; B2R4Z7; Q5RKS5; Q6LCA7 

Genbank Protein ID

 AF161481; AL021546; AK312006; CH471054; BC002638; BC055313; U75688 

Genbank Nucleotide ID

 AAF29096.1; CAA16495.1; BAG34944.1; EAW98192.1; AAH02638.1; AAH55313.1; AAR00584.1 

Protein Name

 TP53-regulated inhibitor of apoptosis 1 

Protein Synonyms/Alias

 Protein 15E1.1; WF-1; p53-inducible cell-survival factor; p53CSV 

Gene Name

 TRIAP1 

Gene Synonyms/Alias

 15E1.1; HSPC132 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	FNRWFAEKFLKGDSS	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 Acetylation; Apoptosis; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 76 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:HGNC.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:HGNC.
 GO:0043066; P:negative regulation of apoptotic process; IMP:HGNC. 

Interpro

 IPR007918; MDM35_apoptosis. 

Pfam

 PF05254; UPF0203 

SMART

  

PROSITE

  

PRINTS