| Tag | Content |
|---|
| CPLM ID | CPLM-006659 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Blue copper oxidase CueO |
Protein Synonyms/Alias | Copper efflux oxidase |
Gene Name | cueO |
Gene Synonyms/Alias | yacK; b0123; JW0119 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 485 | NVSEVLVKFNHDAPK | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Probably involved in periplasmic detoxification of copper by oxidizing Cu(+) to Cu(2+) and thus preventing its uptake into the cytoplasm. Possesses phenoloxidase and ferroxidase activities and might be involved in the production of polyphenolic compounds and the prevention of oxidative damage in the periplasm. |
Sequence Annotation | DOMAIN 67 163 Plastocyanin-like 1.
DOMAIN 164 410 Plastocyanin-like 2.
DOMAIN 411 516 Plastocyanin-like 3.
METAL 101 101 Copper 1; type 2.
METAL 103 103 Copper 2; type 3.
METAL 141 141 Copper 2; type 3.
METAL 143 143 Copper 3; type 3.
METAL 443 443 Copper 4; type 1.
METAL 446 446 Copper 1; type 2.
METAL 448 448 Copper 3; type 3.
METAL 499 499 Copper 3; type 3.
METAL 500 500 Copper 4; type 1.
METAL 501 501 Copper 2; type 3.
METAL 505 505 Copper 4; type 1.
METAL 510 510 Copper 4; type 1. |
Keyword | 3D-structure; Complete proteome; Copper; Direct protein sequencing; Metal-binding; Oxidoreductase; Periplasm; Reference proteome; Repeat; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 516 AA |
Protein Sequence | MQRRDFLKYS VALGVASALP LWSRAVFAAE RPTLPIPDLL TTDARNRIQL TIGAGQSTFG 60
GKTATTWGYN GNLLGPAVKL QRGKAVTVDI YNQLTEETTL HWHGLEVPGE VDGGPQGIIP 120
PGGKRSVTLN VDQPAATCWF HPHQHGKTGR QVAMGLAGLV VIEDDEILKL MLPKQWGIDD 180
VPVIVQDKKF SADGQIDYQL DVMTAAVGWF GDTLLTNGAI YPQHAAPRGW LRLRLLNGCN 240
ARSLNFATSD NRPLYVIASD GGLLPEPVKV SELPVLMGER FEVLVEVNDN KPFDLVTLPV 300
SQMGMAIAPF DKPHPVMRIQ PIAISASGAL PDTLSSLPAL PSLEGLTVRK LQLSMDPMLD 360
MMGMQMLMEK YGDQAMAGMD HSQMMGHMGH GNMNHMNHGG KFDFHHANKI NGQAFDMNKP 420
MFAAAKGQYE RWVISGVGDM MLHPFHIHGT QFRILSENGK PPAAHRAGWK DTVKVEGNVS 480
EVLVKFNHDA PKEHAYMAHC HLLEHEDTGM MLGFTV 516 |
Gene Ontology | GO:0042597; C:periplasmic space; IDA:EcoliWiki. GO:0005507; F:copper ion binding; IDA:EcoliWiki. GO:0016722; F:oxidoreductase activity, oxidizing metal ions; IDA:EcoliWiki. |
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Pfam | |
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