| Tag | Content |
|---|
| CPLM ID | CPLM-014198 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-associated domain-containing protein 1 |
Protein Synonyms/Alias | UBA domain-containing protein 1; E3 ubiquitin-protein ligase subunit KPC2; Kip1 ubiquitination-promoting complex protein 2 |
Gene Name | Ubac1 |
Gene Synonyms/Alias | Kpc2; Ubadc1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 154 | DFQTELRKILVSLIE | ubiquitination | [1] | | 178 | PDAVELFKKANAMLD | ubiquitination | [1] | | 179 | DAVELFKKANAMLDE | ubiquitination | [1] | | 309 | MEMGFDEKEVIDALR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity). |
Sequence Annotation | DOMAIN 14 98 Ubiquitin-like.
DOMAIN 187 231 UBA 1.
DOMAIN 292 332 UBA 2.
DOMAIN 357 396 STI1. |
Keyword | Complete proteome; Cytoplasm; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 409 AA |
Protein Sequence | MFVQEEKIFA GKVLRLHICA ADGSEWLEEA TEDTSVEKLK ESCLKHGAHG SLEDPKNVTH 60
HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRAPSPI PKMADVSAEE KKKQEQKAPD 120
KDAILRATAN LPACSTDRTA VQTTMRDFQT ELRKILVSLI EVAQKLLALN PDAVELFKKA 180
NAMLDEDEDE RVDETALRQL TEMGFPESRA SKALRLNHMS VPQAMEWLIE HSEDPAIDTP 240
LPGHAAQAEA SAAAATSSSS SEAAVGTSVE DEESRDELTE IFKKIRRKKE FRADARAVIS 300
LMEMGFDEKE VIDALRVNNN QQNAACEWLL GDRKPSPEEL DQGIDPNSPL FQAILDNPVV 360
QLGLTNPKTL LAFEDMLENP LNSTQWMNDP ETGPVMLQIS RIFQTLNRT 409 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0005886; C:plasma membrane; IEA:Compara. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
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