CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010083
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Putative Xaa-Pro aminopeptidase 
Protein Synonyms/Alias
 X-Pro aminopeptidase; Aminoacylproline aminopeptidase; Aminopeptidase P; APP 
Gene Name
 pepP 
Gene Synonyms/Alias
 MPN_470; MP371 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
73TAIDPLVKVELFTTYacetylation[1]
349KSVWLSAKIPRAF**acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819
Functional Description
  
Sequence Annotation
 METAL 213 213 Manganese 2 (By similarity).
 METAL 224 224 Manganese 1 (By similarity).
 METAL 224 224 Manganese 2 (By similarity).
 METAL 290 290 Manganese 1 (By similarity).
 METAL 319 319 Manganese 1 (By similarity).
 METAL 333 333 Manganese 1 (By similarity).
 METAL 333 333 Manganese 2 (By similarity).  
Keyword
 Aminopeptidase; Complete proteome; Hydrolase; Manganese; Metal-binding; Metalloprotease; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 354 AA 
Protein Sequence
MHNELQQKLA VLHKLLQDNK ADAILIGSDQ NRFWLTGFPS SAGWLVVHKQ RVNLFIDGRY 60
FEAAKTAIDP LVKVELFTTY KQVKALCEQV GVKHLLIEGD YLTFNYQNFI KELCAQYTVI 120
NAQEIRRQKL PSEILAIEKV VEITRKVAVK LKRFIQPGMT ELFIAQWITD QLVKAGGAKN 180
SFDPIVATGK NGANPHHKPS KLKVKSGDFV TCDFGTIYNG YCSDITRTFL VGKKPNNEVL 240
LKAYKKVDEA NMAGINAANT QLTGAEVDKV CRDIIEASEF KDYFVHSTGH GVGLDIHEMP 300
NVSTSYNKLL CENAVITIEP GIYIPSVGGI RIEDMVLVKD HKSVWLSAKI PRAF 354 
Gene Ontology
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0009987; P:cellular process; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR000587; Creatinase.
 IPR000994; Pept_M24_structural-domain.
 IPR001131; Peptidase_M24B_aminopep-P_CS. 
Pfam
 PF01321; Creatinase_N
 PF00557; Peptidase_M24 
SMART
  
PROSITE
 PS00491; PROLINE_PEPTIDASE 
PRINTS