UniProt Accession

 PTOV1_HUMAN; Q86YD1; Q6UXX7; Q96BU3; Q9HBN4; Q9NYL1 

Genbank Protein ID

 AF238381; AJ617480; AF218026; AY358168; CH471177; BC015172; BC042921 

Genbank Nucleotide ID

 AAF70635.1; CAE84582.1; AAG17268.1; AAQ88535.1; EAW52558.1; AAH15172.1; AAH42921.1 

Protein Name

 Prostate tumor-overexpressed gene 1 protein 

Protein Synonyms/Alias

 PTOV-1; Activator interaction domain-containing protein 2 

Gene Name

 PTOV1 

Gene Synonyms/Alias

 ACID2; PP642; UNQ6127/PRO20092 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	SEHRLSNKLLAWSGV	ubiquitination	[1]
72	GVLEWQEKRRPYSDS	ubiquitination	[1]
144	NRDCDSLKGLCRIMG	ubiquitination	[1]
180	LLYSSKKKIFMGLIP	ubiquitination	[1]
205	RQVITTRKQAVGPGG	ubiquitination	[1, 2]
224	PVQIVNNKFLAWSGV	ubiquitination	[2]
299	LVQFHFTKDLETLKS	ubiquitination	[1, 2]
305	TKDLETLKSLCRIMD	ubiquitination	[1]
318	MDNGFRRKSSLASSP	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation. 

Sequence Annotation

 REGION 184 416 Interaction with FLOT1.  

Keyword

 Activator; Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR021394; Mediator_Med25. 

Pfam

 PF11232; Med25 

SMART

  

PROSITE

  

PRINTS