CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012616
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ALX homeobox protein 1 
Protein Synonyms/Alias
 Cartilage homeoprotein 1; CART-1 
Gene Name
 ALX1 
Gene Synonyms/Alias
 CART1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
131DSNVSSSKKRRHRTTacetylation[1]
Reference
 [1] P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain.
 Iioka T, Furukawa K, Yamaguchi A, Shindo H, Yamashita S, Tsukazaki T.
 J Bone Miner Res. 2003 Aug;18(8):1419-29. [PMID: 12929931] 
Functional Description
 Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development. 
Sequence Annotation
 DNA_BIND 132 191 Homeobox.
 MOTIF 306 319 OAR.
 MOD_RES 131 131 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Activator; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 326 AA 
Protein Sequence
MEFLSEKFAL KSPPSKNSDF YMGAGGPLEH VMETLDNESF YSKASAGKCV QAFGPLPRAE 60
HHVRLERTSP CQDSSVNYGI TKVEGQPLHT ELNRAMDNCN SLRMSPVKGM QEKGELDELG 120
DKCDSNVSSS KKRRHRTTFT SLQLEELEKV FQKTHYPDVY VREQLALRTE LTEARVQVWF 180
QNRRAKWRKR ERYGQIQQAK SHFAATYDIS VLPRTDSYPQ IQNNLWAGNA SGGSVVTSCM 240
LPRDTSSCMT PYSHSPRTDS SYTGFSNHQN QFSHVPLNNF FTDSLLTGAT NGHAFETKPE 300
FERRSSSIAV LRMKAKEHTA NISWAM 326 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0007420; P:brain development; TAS:ProtInc.
 GO:0001502; P:cartilage condensation; TAS:ProtInc.
 GO:0030326; P:embryonic limb morphogenesis; IEA:Compara.
 GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Compara.
 GO:0014031; P:mesenchymal cell development; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like.
 IPR003654; OAR_dom. 
Pfam
 PF00046; Homeobox
 PF03826; OAR 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2
 PS50803; OAR 
PRINTS