UniProt Accession

 HERP1_MOUSE; Q9JJK5 

Genbank Protein ID

 AB034991 

Genbank Nucleotide ID

 BAB07892.1 

Protein Name

 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein 

Protein Synonyms/Alias

  

Gene Name

 Herpud1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
75	CLQDLLPKQEKRHVL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). 

Sequence Annotation

 DOMAIN 10 72 Ubiquitin-like.  

Keyword

 Complete proteome; Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 391 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IDA:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:MGI.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IMP:MGI.
 GO:0031396; P:regulation of protein ubiquitination; IMP:MGI.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI. 

Interpro

 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF00240; ubiquitin 

SMART

 SM00213; UBQ 

PROSITE

 PS50053; UBIQUITIN_2 

PRINTS