CPLM-004986

Genbank Nucleotide ID

Protein Synonyms/Alias

Mast cell growth factor; MGF; Stem cell factor; SCF; c-Kit ligand; Soluble KIT ligand; sKITLG

Homo sapiens (Human)

Position	Peptide	Type	References
128	KDLKKSFKSPEPRLF	ubiquitination	[1]
238	EISMLQEKEREFQEV	ubiquitination	[1]

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

CARBOHYD 90 90 N-linked (GlcNAc...); partial.
CARBOHYD 118 118 N-linked (GlcNAc...); partial.
CARBOHYD 145 145 N-linked (GlcNAc...).
CARBOHYD 167 167 O-linked (GalNAc...).
CARBOHYD 168 168 O-linked (GalNAc...).
CARBOHYD 180 180 O-linked (GalNAc...).
CARBOHYD 195 195 N-linked (GlcNAc...) (Potential).
DISULFID 29 114
DISULFID 68 163

3D-structure; Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Growth factor; Membrane; Polymorphism; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0005576; C:extracellular region; TAS:Reactome.
GO:0005615; C:extracellular space; IEA:Compara.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; NAS:UniProtKB.
GO:0005173; F:stem cell factor receptor binding; NAS:UniProtKB.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
GO:0008283; P:cell proliferation; TAS:ProtInc.
GO:0035162; P:embryonic hemopoiesis; IDA:DFLAT.
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.
GO:0035234; P:germ cell programmed cell death; IEA:Compara.
GO:0045087; P:innate immune response; TAS:Reactome.
GO:0008584; P:male gonad development; IEP:UniProtKB.
GO:0033026; P:negative regulation of mast cell apoptotic process; IEA:Compara.
GO:0001755; P:neural crest cell migration; IEA:Compara.
GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.
GO:0045740; P:positive regulation of DNA replication; IDA:BHF-UCL.
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
GO:0070668; P:positive regulation of mast cell proliferation; IEA:Compara.
GO:0045636; P:positive regulation of melanocyte differentiation; IEA:Compara.
GO:0002763; P:positive regulation of myeloid leukocyte differentiation; IEA:Compara.
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
GO:0046579; P:positive regulation of Ras protein signal transduction; IEA:Compara.

IPR009079; 4_helix_cytokine-like_core.
IPR012351; 4_helix_cytokine_core.
IPR003452; SCF.