UniProt Accession

 CAH14_MOUSE; Q9WVT6 

Genbank Protein ID

 AB005450; BC046995 

Genbank Nucleotide ID

 BAA78709.1; AAH46995.1 

Protein Name

 Carbonic anhydrase 14 

Protein Synonyms/Alias

 Carbonate dehydratase XIV; Carbonic anhydrase XIV; CA-XIV 

Gene Name

 Ca14 

Gene Synonyms/Alias

 Car14; Catm 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
324	KKRLGNRKSVVFTSA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Reversible hydration of carbon dioxide. 

Sequence Annotation

 REGION 217 218 Substrate binding (By similarity).
 ACT_SITE 84 84 Proton acceptor (By similarity).
 ACT_SITE 144 144 By similarity.
 METAL 109 109 Zinc; catalytic.
 METAL 111 111 Zinc; catalytic.
 METAL 135 135 Zinc; catalytic.
 MOD_RES 325 325 Phosphoserine (By similarity).
 CARBOHYD 213 213 N-linked (GlcNAc...).
 DISULFID 40 221  

Keyword

 3D-structure; Complete proteome; Disulfide bond; Glycoprotein; Lyase; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Signal; Transmembrane; Transmembrane helix; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 337 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004089; F:carbonate dehydratase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR001148; Carbonic_anhydrase_a.
 IPR023561; Carbonic_anhydrase_a-class.
 IPR018431; Carbonic_anhydrase_CA14. 

Pfam

 PF00194; Carb_anhydrase 

SMART

 SM01057; Carb_anhydrase 

PROSITE

 PS00162; ALPHA_CA_1
 PS51144; ALPHA_CA_2 

PRINTS