UniProt Accession

 EIF3D_RAT; Q6AYK8 

Genbank Protein ID

 CH473950; BC079005 

Genbank Nucleotide ID

 EDM15894.1; AAH79005.1 

Protein Name

 Eukaryotic translation initiation factor 3 subunit D 

Protein Synonyms/Alias

 eIF3d; Eukaryotic translation initiation factor 3 subunit 7; eIF-3-zeta 

Gene Name

 Eif3d 

Gene Synonyms/Alias

 Eif3s7 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
275	VVQRVGSKLFFDKRD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). 

Sequence Annotation

 MOD_RES 67 67 Phosphoserine (By similarity).
 MOD_RES 318 318 Phosphotyrosine (By similarity).
 MOD_RES 528 528 Phosphoserine (By similarity).
 MOD_RES 529 529 Phosphoserine (By similarity).
 MOD_RES 548 548 Phosphothreonine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 548 AA 

Protein Sequence

Gene Ontology

 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
 GO:0003743; F:translation initiation factor activity; IEA:HAMAP.
 GO:0001732; P:formation of translation initiation complex; IEA:Compara.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP.
 GO:0006413; P:translational initiation; ISS:UniProtKB. 

Interpro

 IPR007783; eif3d. 

Pfam

 PF05091; eIF-3_zeta 

SMART

  

PROSITE

  

PRINTS