UniProt Accession

 COPD_MOUSE; Q5XJY5; Q91W48 

Genbank Protein ID

 AK028556; CH466522; BC017124; BC023728; BC033387; BC034754; BC083152 

Genbank Nucleotide ID

 BAC26007.1; EDL25614.1; AAH17124.1; AAH23728.1; AAH33387.1; AAH34754.1; AAH83152.1 

Protein Name

 Coatomer subunit delta 

Protein Synonyms/Alias

 Archain; Delta-coat protein; Delta-COP 

Gene Name

 Arcn1 

Gene Synonyms/Alias

 Copd 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
142	EMDSHEEKVFRAVRE	acetylation	[1]
142	EMDSHEEKVFRAVRE	ubiquitination	[2]
233	LKLGAKGKEVDNFVD	acetylation	[3, 4]
233	LKLGAKGKEVDNFVD	ubiquitination	[2]
241	EVDNFVDKLKSEGET	acetylation	[4]
241	EVDNFVDKLKSEGET	ubiquitination	[2]
243	DNFVDKLKSEGETIM	ubiquitination	[2]
256	IMSSNMGKRTSEATK	ubiquitination	[2]
309	MLRISDDKFGRIRLH	ubiquitination	[2]
335	QTHPNVDKKLFTAES	acetylation	[5]
336	THPNVDKKLFTAESL	ubiquitination	[2]
347	AESLIGLKNPEKSFP	ubiquitination	[2]
351	IGLKNPEKSFPVNSD	acetylation	[1, 3, 4]
351	IGLKNPEKSFPVNSD	succinylation	[4]
351	IGLKNPEKSFPVNSD	ubiquitination	[2]
363	NSDVGVLKWRLQTTE	acetylation	[3]
448	CLPVIDAKNKSGSLE	ubiquitination	[2]
485	YCNIQVTKVTQVDGN	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). 

Sequence Annotation

 DOMAIN 271 511 MHD.
 MOD_RES 233 233 N6-acetyllysine (By similarity).
 MOD_RES 309 309 N6-acetyllysine (By similarity).
 MOD_RES 493 493 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 511 AA 

Protein Sequence

Gene Ontology

 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030126; C:COPI vesicle coat; IEA:InterPro.
 GO:0030137; C:COPI-coated vesicle; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0008344; P:adult locomotory behavior; IMP:MGI.
 GO:0021691; P:cerebellar Purkinje cell layer maturation; IMP:MGI.
 GO:0048193; P:Golgi vesicle transport; IMP:MGI.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:InterPro. 

Interpro

 IPR022775; AP_mu_sigma_su.
 IPR008968; Clathrin_mu_C.
 IPR027059; Coatomer_dsu.
 IPR011012; Longin-like_dom. 

Pfam

 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 

SMART

  

PROSITE

 PS51072; MHD 

PRINTS