CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 430 
Protein Synonyms/Alias
  
Gene Name
 ZNF430 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
5***MENLKSGVYPLKubiquitination[1]
12KSGVYPLKEASGCPGubiquitination[1]
32LVYSFYEKGPLTFRDubiquitination[1]
137VILRRYGKCGHEDLQubiquitination[1]
188KYVNVFYKFSNPNIQubiquitination[2]
259RRIHTGEKPYKCEQCubiquitination[1]
262HTGEKPYKCEQCGKAubiquitination[1]
296YRCEECGKTFNRSSHubiquitination[1]
380YKCEECGKAFYRFSYubiquitination[1]
486HSGEKPYKCEECGKAubiquitination[1]
504FSNLTKHKITHIGDTubiquitination[1]
520YKYLECDKAFSQSSTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 35 107 KRAB.
 ZN_FING 205 227 C2H2-type 1.
 ZN_FING 233 255 C2H2-type 2.
 ZN_FING 261 283 C2H2-type 3.
 ZN_FING 289 311 C2H2-type 4.
 ZN_FING 317 339 C2H2-type 5.
 ZN_FING 345 367 C2H2-type 6.
 ZN_FING 373 395 C2H2-type 7.
 ZN_FING 401 423 C2H2-type 8.
 ZN_FING 429 451 C2H2-type 9.
 ZN_FING 457 479 C2H2-type 10.
 ZN_FING 485 507 C2H2-type 11.
 ZN_FING 513 535 C2H2-type 12; degenerate.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MENLKSGVYP LKEASGCPGA DRNLLVYSFY EKGPLTFRDV AIEFSLEEWQ CLDTAQQDLY 60
RKVMLENYRN LVFLAGIAVS KPDLITCLEQ GKEPWNMKRH AMVDQPPVTY SHFAQDLWPE 120
QGIKDSFQEV ILRRYGKCGH EDLQLRTGCK SVDECNLHKE CYDELNQCLT TTQSEIFQYD 180
KYVNVFYKFS NPNIQKIRHT GKKPFKCKKC DKSFCMLLHL TQHKRIHIRE NSYQCEECGK 240
VFNWFSTLTR HRRIHTGEKP YKCEQCGKAF KQSSTLTTHK IIHTGEKPYR CEECGKTFNR 300
SSHLTTHKRI HTGEKPYRCE ECGRAFNRSS HLTTHKIIHT GEKPYKCEEC GKAFNQSSTL 360
TTHKIIHAGE KPYKCEECGK AFYRFSYLTK HKIIHTGEKF YKCEECGKGF NWSSTLTKHK 420
RIHTGEKPYK CEQCGKAFNE SSNLTAHKII HTGEKPYKCE ECGKAFNRSP KLTAHKVIHS 480
GEKPYKCEEC GKAFNQFSNL TKHKITHIGD TSYKYLECDK AFSQSSTLTK HKVIHTGEKP 540
YNCEEYGKAF NQSSNLIEQS NSYWRETLQM 570 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS