| Tag | Content |
|---|
| CPLM ID | CPLM-018234 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Apoptosis-enhancing nuclease |
Protein Synonyms/Alias | Interferon-stimulated 20 kDa exonuclease-like 1 |
Gene Name | AEN |
Gene Synonyms/Alias | ISG20L1; SBBI58 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 101 | SRRPAPGKASGPLPS | ubiquitination | [1] | | 235 | TRARVSLKDLALQLL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. |
Sequence Annotation | DOMAIN 110 266 Exonuclease.
MOTIF 27 35 Nucleolar localization signal.
MOTIF 165 188 Nuclear localization signal. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; DNA damage; Exonuclease; Hydrolase; Nuclease; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 325 AA |
Protein Sequence | MVPREAPESA QCLCPSLTIP NAKDVLRKRH KRRSRQHQRF MARKALLQEQ GLLSMPPEPG 60
SSPLPTPFGA ATATEAASSG KQCLRAGSGS APCSRRPAPG KASGPLPSKC VAIDCEMVGT 120
GPRGRVSELA RCSIVSYHGN VLYDKYIRPE MPIADYRTRW SGITRQHMRK AVPFQVAQKE 180
ILKLLKGKVV VGHALHNDFQ ALKYVHPRSQ TRDTTYVPNF LSEPGLHTRA RVSLKDLALQ 240
LLHKKIQVGQ HGHSSVEDAT TAMELYRLVE VQWEQQEARS LWTCPEDREP DSSTDMEQYM 300
EDQYWPDDLA HGSRGGAREA QDRRN 325 |
Gene Ontology | GO:0005730; C:nucleolus; IDA:UniProtKB. GO:0005654; C:nucleoplasm; IDA:UniProtKB. GO:0004527; F:exonuclease activity; IDA:UniProtKB. GO:0003676; F:nucleic acid binding; IEA:InterPro. GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IDA:UniProtKB. GO:0010212; P:response to ionizing radiation; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |