UniProt Accession

 CDIP1_HUMAN; Q9H305; A8K7M1; B4DFU1; B4DY75; D3DUD6; Q96ID8; Q9H0Q4; Q9P112 

Genbank Protein ID

 AF131218; AF195661; DQ167023; AL136698; CR533446; AK292036; AK294257; AK302297; AL833853; AC007606; AC023830; CH471112; CH471112; CH471112; CH471112; CH471112; BC002882; BC007604 

Genbank Nucleotide ID

 AAF26619.1; AAG35583.1; AAZ94626.1; CAB66633.1; CAG38477.1; BAF84725.1; BAG57552.1; BAG63637.1; CAD38712.1; EAW85291.1; EAW85292.1; EAW85293.1; EAW85294.1; EAW85296.1; AAH02882.1; AAH07604.1 

Protein Name

 Cell death-inducing p53-target protein 1 

Protein Synonyms/Alias

 Cell death involved p53-target; Cell death-inducing protein; LITAF-like protein; Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein; Transmembrane protein I1 

Gene Name

 CDIP1 

Gene Synonyms/Alias

 C16orf5; CDIP; LITAFL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	TAPLLEEKSGAPPTP	ubiquitination	[1, 2, 3]
198	THTCPSCKAYIYTYK	ubiquitination	[2, 3, 4, 5]
205	KAYIYTYKRLC****	ubiquitination	[2, 3, 4, 5]

Reference

 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner. 

Sequence Annotation

  

Keyword

 Alternative splicing; Apoptosis; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0006917; P:induction of apoptosis; IDA:MGI.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:MGI.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IGI:MGI. 

Interpro

 IPR006629; LITAF. 

Pfam

 PF10601; zf-LITAF-like 

SMART

 SM00714; LITAF 

PROSITE

  

PRINTS