UniProt Accession

 ARL6_MOUSE; O88848; Q3TY77 

Genbank Protein ID

 AF031903; AK158832; AK003778 

Genbank Nucleotide ID

 AAC62194.1; BAE34686.1; BAB22990.1 

Protein Name

 ADP-ribosylation factor-like protein 6 

Protein Synonyms/Alias

  

Gene Name

 Arl6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
106	KLRMVVAKEELDTLL	acetylation	[1]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (By similarity). Isoform 2 may be required for proper retinal function and organization. 

Sequence Annotation

 NP_BIND 24 31 GTP (By similarity).
 NP_BIND 69 73 GTP (By similarity).
 NP_BIND 130 133 GTP (By similarity).
 METAL 50 50 Magnesium (By similarity).
 BINDING 50 50 GTP (By similarity).
 BINDING 72 72 GTP; via amide nitrogen (By similarity).
 BINDING 164 164 GTP; via amide nitrogen (By similarity).
 LIPID 2 2 N-myristoyl glycine (Potential).  

Keyword

 Alternative splicing; Cell membrane; Cell projection; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Myristate; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 186 AA 

Protein Sequence

Gene Ontology

 GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
 GO:0035085; C:cilium axoneme; ISS:UniProtKB.
 GO:0060170; C:cilium membrane; IEA:UniProtKB-SubCell.
 GO:0030117; C:membrane coat; ISS:UniProtKB.
 GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; ISS:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; ISS:UniProtKB.
 GO:0042384; P:cilium assembly; ISS:UniProtKB.
 GO:0045444; P:fat cell differentiation; IEP:BHF-UCL.
 GO:0006471; P:protein ADP-ribosylation; ISS:MGI.
 GO:0051258; P:protein polymerization; ISS:UniProtKB.
 GO:0006612; P:protein targeting to membrane; ISS:UniProtKB.
 GO:0007265; P:Ras protein signal transduction; ISS:MGI.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00328; SAR1GTPBP.