| Tag | Content |
|---|
| CPLM ID | CPLM-013614 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable E3 ubiquitin-protein ligase HERC4 |
Protein Synonyms/Alias | HECT domain and RCC1-like domain-containing protein 4 |
Gene Name | HERC4 |
Gene Synonyms/Alias | KIAA1593 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 218 | IFGWGRNKFGQLGLN | ubiquitination | [1] | | 237 | RYVPNLLKSLRSQKI | ubiquitination | [1] | | 469 | AARLLFHKLIQPDHP | ubiquitination | [1] | | 488 | QVAASLEKNLIPKLT | ubiquitination | [1] | | 882 | GADTAVNKQNRQEFV | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity). |
Sequence Annotation | REPEAT 1 51 RCC1 1.
REPEAT 52 101 RCC1 2.
REPEAT 102 154 RCC1 3.
REPEAT 156 207 RCC1 4.
REPEAT 208 259 RCC1 5.
REPEAT 261 311 RCC1 6.
REPEAT 313 368 RCC1 7.
DOMAIN 730 1057 HECT.
ACT_SITE 1025 1025 Glycyl thioester intermediate (By |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Differentiation; Ligase; Reference proteome; Repeat; Spermatogenesis; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1057 AA |
Protein Sequence | MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG 120
SEECIRVPRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC WGQNKYGQLG LGTDCKKQTS 180
PQLLKSLLGI PFMQVAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPNLLKSLR 240
SQKIVYICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTEIA 300
CGRQHTSAFV PSSGRIYSFG LGGNGQLGTG STSNRKSPFT VKGNWYPYNG QCLPDIDSEE 360
YFCVKRIFSG GDQSFSHYSS PQNCGPPDDF RCPNPTKQIW TVNEALIQKW LSYPSGRFPV 420
EIANEIDGTF SSSGCLNGSF LAVSNDDHYR TGTRFSGVDM NAARLLFHKL IQPDHPQISQ 480
QVAASLEKNL IPKLTSSLPD VEALRFYLTL PECPLMSDSN NFTTIAIPFG TALVNLEKAP 540
LKVLENWWSV LEPPLFLKIV ELFKEVVVHL LKLYKIGIPP SERRIFNSFL HTALKVLEIL 600
HRVNEKMGQI IQYDKFYIHE VQELIDIRND YINWVQQQAY GMLADIPVTI CTYPFVFDAQ 660
AKTTLLQTDA VLQMQMAIDQ AHRQNVSSLF LPVIESVNPC LILVVRRENI VGDAMEVLRK 720
TKNIDYKKPL KVIFVGEDAV DAGGVRKEFF LLIMRELLDP KYGMFRYYED SRLIWFSDKT 780
FEDSDLFHLI GVICGLAIYN CTIVDLHFPL ALYKKLLKKK PSLDDLKELM PDVGRSMQQL 840
LDYPEDDIEE TFCLNFTITV ENFGATEVKE LVLNGADTAV NKQNRQEFVD AYVDYIFNKS 900
VASLFDAFHA GFHKVCGGKV LLLFQPNELQ AMVIGNTNYD WKELEKNTEY KGEYWAEHPT 960
IKIFWEVFHE LPLEKKKQFL LFLTGSDRIP ILGMKSLKLV IQSTGGGEEY LPVSHTCFNL 1020
LDLPKYTEKE TLRSKLIQAI DHNEGFSLI 1049 |
Gene Ontology | GO:0005737; C:cytoplasm; IBA:RefGenome. GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IBA:RefGenome. GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. GO:0007283; P:spermatogenesis; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |