| Tag | Content |
|---|
| CPLM ID | CPLM-015575 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FYVE, RhoGEF and PH domain-containing protein 6 |
Protein Synonyms/Alias | Zinc finger FYVE domain-containing protein 24 |
Gene Name | FGD6 |
Gene Synonyms/Alias | KIAA1362; ZFYVE24 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 165 | KCDLYGEKAKNQGGV | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). |
Sequence Annotation | DOMAIN 871 1060 DH.
DOMAIN 1089 1183 PH 1.
DOMAIN 1333 1429 PH 2.
ZN_FING 1222 1281 FYVE-type.
MOD_RES 515 515 Phosphoserine.
MOD_RES 692 692 Phosphoserine.
MOD_RES 721 721 Phosphoserine.
MOD_RES 1197 1197 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Guanine-nucleotide releasing factor; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1430 AA |
Protein Sequence | MTSAAEIKKP PVAPKPKFVV ANNKPAPPPI APKPDIVISS VPQSTKKMKP AIAPKPKVLK 60
TSPVREIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGN QSNDYISPMC SCSSECIHKL 120
GHRENLCVKQ LVLEPLEMNE NLENSKIDET LTIKTRSKCD LYGEKAKNQG GVVLKASVLE 180
EELKDALIHQ MPPFISAQKH RPTDSPEMNG GCNSNGQFRI EFADLSPSPS SFEKVPDHHS 240
CHLQLPSDEC EHFETCQDDS EKSNNCFQSS ELEALENGKR STLISSDGVS KKSEVKDLGP 300
LEIHLVPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC LTENSLKINK 360
ISVLHQNVLC KQEQVDKMKL GNKSELNMES NSDAQDLVNS QKAMCNETTS FEKMAPSFDK 420
DSNLSSDSTT VDGSSMSLAV DEGTGFIRCT VSMSLPKQLK LTCNEHLQSG RNLGVSAPQM 480
QKESVIKEEN SLRIVPKKPQ RHSLPATGVL KKAASEELLE KSSYPSSEEK SSEKSLERNH 540
LQHLCAQNRG VSSSFDMPKR ASEKPVWKLP HPILPFSGNP EFLKSVTVSS NSEPSTALTK 600
PRAKSLSAMD VEKCTKPCKD STKKNSFKKL LSMKLSICFM KSDFQKFWSK SSQLGDTTTG 660
HLSSGEQKGI ESDWQGLLVG EEKRSKPIKA YSTENYSLES QKKRKKSRGQ TSAANGLRAE 720
SLDDQMLSRE SSSQAPYKSV TSLCAPEYEN IRHYEEIPEY ENLPFIMAIR KTQELEWQNS 780
SSMEDADANV YEVEEPYEAP DGQLQLGPRH QHSSSGASQE EQNDLGLGDL PSDEEEIINS 840
SDEDDVSSES SKGEPDPLED KQDEDNGMKS KVHHIAKEIM SSEKVFVDVL KLLHIDFRDA 900
VAHASRQLGK PVIEDRILNQ ILYYLPQLYE LNRDLLKELE ERMLHWTEQQ RIADIFVKKG 960
PYLKMYSTYI KEFDKNIALL DEQCKKNPGF AAVVREFEMS PRCANLALKH YLLKPVQRIP 1020
QYRLLLTDYL KNLIEDAGDY RDTQDALAVV IEVANHANDT MKQGDNFQKL MQIQYSLNGH 1080
HEIVQPGRVF LKEGILMKLS RKVMQPRMFF LFNDALLYTT PVQSGMYKLN NMLSLAGMKV 1140
RKPTQEAYQN ELKIESVERS FILSASSATE RDEWLEAISR AIEEYAKKRI TFCPSRSLDE 1200
ADSENKEEVS PLGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKI VCQACSSNKY 1260
GLDYLKNQPA RVCEHCFQEL QKLDHQHSPR IGSPGNHKSP SSALSSVLHS IPSGRKQKKI 1320
PAALKEVSAN TEDSSMSGYL YRSKGNKKPW KHFWFVIKNK VLYTYAASED VAALESQPLL 1380
GFTVIQVKDE NSESKVFQLL HKNMLFYVFK AEDAHSAQKW IEAFQEGTIL 1430 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; ISS:UniProtKB. GO:0030027; C:lamellipodium; ISS:UniProtKB. GO:0001726; C:ruffle; ISS:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0031267; F:small GTPase binding; ISS:UniProtKB. GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB. GO:0046847; P:filopodium assembly; ISS:UniProtKB. GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB. GO:0008360; P:regulation of cell shape; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |