UniProt Accession

 A6NN80_HUMAN; A6NN80 

Genbank Protein ID

 AC008641; CH471062 

Genbank Nucleotide ID

 EAW61687.1 

Protein Name

 Annexin 

Protein Synonyms/Alias

  

Gene Name

 ANXA6 

Gene Synonyms/Alias

 hCG_39152 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MAKPAQGAKY	acetylation	[1]
9	AKPAQGAKYRGSIHD	acetylation	[1]
9	AKPAQGAKYRGSIHD	ubiquitination	[2]
40	MKGFGSDKEAILDII	acetylation	[3]
40	MKGFGSDKEAILDII	ubiquitination	[2]
63	QEVCQSYKSLYGKDL	acetylation	[1]
63	QEVCQSYKSLYGKDL	ubiquitination	[1, 2]
68	SYKSLYGKDLIADLK	acetylation	[1, 3]
68	SYKSLYGKDLIADLK	ubiquitination	[2, 4]
81	LKYELTGKFERLIVG	acetylation	[1, 3]
81	LKYELTGKFERLIVG	ubiquitination	[1, 2, 4]
99	PPAYCDAKEIKDAIS	acetylation	[1]
99	PPAYCDAKEIKDAIS	ubiquitination	[1, 2]
102	YCDAKEIKDAISGIG	acetylation	[1]
102	YCDAKEIKDAISGIG	ubiquitination	[1, 2, 5, 6]
113	SGIGTDEKCLIEILA	ubiquitination	[2, 5]
135	HQLVAAYKDAYERDL	ubiquitination	[1, 2, 4, 5, 7]
220	LVFDEYLKTTGKPIE	ubiquitination	[2]
224	EYLKTTGKPIEASIR	ubiquitination	[2]
240	ELSGDFEKLMLAVVK	ubiquitination	[1, 2]
247	KLMLAVVKCIRSTPE	ubiquitination	[2]
299	IFRTKYEKSLYSMIK	acetylation	[3, 8]
306	KSLYSMIKNDTSGEY	acetylation	[1]
306	KSLYSMIKNDTSGEY	ubiquitination	[2]
370	FNPDADAKALRKAMK	acetylation	[1, 3, 8]
370	FNPDADAKALRKAMK	ubiquitination	[1]
377	KALRKAMKGLGTDED	ubiquitination	[1, 2, 4, 5, 6, 7, 9, 10]
406	QQIRQTFKSHFGRDL	ubiquitination	[1, 2]
418	RDLMTDLKSEISGDL	acetylation	[1, 3, 8]
418	RDLMTDLKSEISGDL	ubiquitination	[2, 5, 6, 10]
442	PPAHYDAKQLKKAME	acetylation	[1, 3]
445	HYDAKQLKKAMEGAG	acetylation	[1]
445	HYDAKQLKKAMEGAG	ubiquitination	[1]
446	YDAKQLKKAMEGAGT	ubiquitination	[2]
456	EGAGTDEKALIEILA	ubiquitination	[1, 2]
478	RAINEAYKEDYHKSL	acetylation	[1, 8]
478	RAINEAYKEDYHKSL	ubiquitination	[1, 2]
483	AYKEDYHKSLEDALS	acetylation	[1, 3]
483	AYKEDYHKSLEDALS	ubiquitination	[2]
534	ADTPSGDKTSLETRF	ubiquitination	[5]
562	RVFQEFIKMTNYDVE	ubiquitination	[5]
594	IVQSVKNKPLFFADK	ubiquitination	[2]
601	KPLFFADKLYKSMKG	ubiquitination	[2]
614	KGAGTDEKTLTRIMV	acetylation	[1, 3]
614	KGAGTDEKTLTRIMV	ubiquitination	[1, 2]
641	EFIEKYDKSLHQAIE	ubiquitination	[2]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [9] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [10] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 667 AA 

Protein Sequence

Gene Ontology

 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002393; AnnexinVI. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00202; ANNEXINVI.