CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036545
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 
Protein Synonyms/Alias
  
Gene Name
 PLCB4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
266LFPFYDAKRAMQIIEubiquitination[1]
1034EIVAQHTKEWSEMINubiquitination[1, 2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1187 AA 
Protein Sequence
MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW RSEGKEGQVL 60
ECSLINSIRS GAIPKDPKIL AALEAVGKSE NDLEGRIVCV CSGTDLVNIS FTYMVAENPE 120
VTKQWVEGLR SIIHNFRANN VSPMTCLKKH WMKLAFMTNT NGKIPVRSIT RTFASGKTEK 180
VIFQALKELG LPSGKNDEIE PTAFSYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD 240
QLVSFLNEHQ RDPRLNEILF PFYDAKRAMQ IIEMYEPDED LKKKGLISSD GFCRYLMSDE 300
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL LAGCRCVELD 360
CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS EYPVILSFEN HCSKYQQYKM 420
SKYCEDLFGD LLLKQALESH PLEPGRALPS PNDLKRKILI KNKRLKPEVE KKQLEALRSM 480
MEAGESASPA NILEDDNEEE IESADQEEEA HPEFKFGNEL SADDLGHKEA VANSVKKASD 540
DLEHENNKKG LVTVEDEQAW MASYKYVGAT TNIHPYLSTM INYAQPVKFQ GFHVAEERNI 600
HYNMSSFNES VGLGYLKTHA IEFVNYNKRQ MSRIYPKGGR VDSSNYMPQI FWNAGCQMVS 660
LNYQTPDLAM QLNQGKFEYN GSCGYLLKPD FMRRPDRTFD PFSETPVDGV IAATCSVQVI 720
SGQFLSDKKI GTYVEVDMYG LPTDTIRKEF RTRMVMNNGL NPVYNEESFV FRKVILPDLA 780
VLRIAVYDDN NKLIGQRILP LDGLQAGYRH ISLRNEGNKP LSLPTIFCNI VLKTYVPDGF 840
GDIVDALSDP KKFLSITEKR ADQMRAMGIE TSDIADVPSD TSKNDKKGKA NTAKANVTPQ 900
SSSELRPTTT AALASGVEAK KGIELIPQVR IEDLKQMKAY LKHLKKQQKE LNSLKKKHAK 960
EHSTMQKLHC TQVDKIVAQY DKEKSTHEKI LEKAMKKKGG SNCLEMKKET EIKIQTLTSD 1020
HKSKVKEIVA QHTKEWSEMI NTHSAEEQEI RDLHLSQQCE LLKKLLINAH EQQTQQLKLS 1080
HDRESKEMRA HQAKISMENS KAISQDKSIK NKAERERRVR ELNSSNTKKF LEERKRLAMK 1140
QSKEMDQLKK VQLEHLEFLE KQNEQAKEMQ QMVKLEAEMD RRPATVV 1187 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0006629; P:lipid metabolic process; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR011992; EF-hand-like_dom.
 IPR011993; PH_like_dom.
 IPR001192; Pinositol_PLipase_C.
 IPR016280; PLC-beta.
 IPR009535; PLC-beta_CS.
 IPR017946; PLC-like_Pdiesterase_TIM-brl.
 IPR015359; PLipase_C_EF-hand-like.
 IPR000909; PLipase_C_PInositol-sp_X_dom.
 IPR001711; PLipase_C_Pinositol-sp_Y. 
Pfam
 PF00168; C2
 PF06631; DUF1154
 PF09279; efhand_like
 PF00388; PI-PLC-X
 PF00387; PI-PLC-Y 
SMART
 SM00239; C2
 SM00148; PLCXc
 SM00149; PLCYc 
PROSITE
 PS50004; C2
 PS50007; PIPLC_X_DOMAIN
 PS50008; PIPLC_Y_DOMAIN 
PRINTS
 PR00390; PHPHLIPASEC.