CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012473
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc transporter ZIP14 
Protein Synonyms/Alias
 LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14 
Gene Name
 SLC39A14 
Gene Synonyms/Alias
 KIAA0062; ZIP14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63SLTLQQLKALLNHLDubiquitination[1]
267SESLPSKKDQEEGVMubiquitination[1]
276QEEGVMEKLQNGDLDubiquitination[2]
297CSSELDGKAPMVDEKubiquitination[3]
326QSACYWLKGVRYSDIacetylation[4]
326QSACYWLKGVRYSDIubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May mediate cellular uptake of nontransferrin-bound iron (By similarity). Broad-scope metal ion transporter with a preference for zinc uptake. 
Sequence Annotation
 MOTIF 251 258 HHHGHXHX-motif.
 MOTIF 376 381 XEXPHE-motif.
 CARBOHYD 77 77 N-linked (GlcNAc...).
 CARBOHYD 102 102 N-linked (GlcNAc...).  
Keyword
 Alternative splicing; Cell membrane; Cell projection; Complete proteome; Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSLGAPAISA ASFLQDLIHR YGEGDSLTLQ 60
QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA HNFSEQSRIG SSELQEFCPT 120
ILQQLDSRAC TSENQENEEN EQTEEGRPSA VEVWGYGLLC VTVISLCSLL GASVVPFMKK 180
TFYKRLLLYF IALAIGTLYS NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI 240
LKILLKQKNE HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM 300
VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI DGLAIGASFT 360
VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF FNFLSACCCY LGLAFGILAG 420
SHFSANWIFA LAGGMFLYIS LADMFPEMNE VCQEDERKGS ILIPFIIQNL GLLTGFTIMV 480
VLTMYSGQIQ IG 492 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:HPA.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0005887; C:integral to plasma membrane; IDA:BHF-UCL.
 GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:Compara.
 GO:0005385; F:zinc ion transmembrane transporter activity; IDA:BHF-UCL.
 GO:0006882; P:cellular zinc ion homeostasis; IDA:BHF-UCL.
 GO:0071578; P:zinc ion transmembrane import; IDA:BHF-UCL. 
Interpro
 IPR003689; ZIP. 
Pfam
 PF02535; Zip 
SMART
  
PROSITE
  
PRINTS