UniProt Accession

 MDH_SALTY; P25077 

Genbank Protein ID

 M95049; X61029; AE006468 

Genbank Nucleotide ID

 AAA27158.1; CAA43363.1; AAL22228.1 

Protein Name

 Malate dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 mdh 

Gene Synonyms/Alias

 STM3359 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
82	ISAGVARKPGMDRSD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity). 

Sequence Annotation

 NP_BIND 7 13 NAD (By similarity).
 NP_BIND 117 119 NAD (By similarity).
 ACT_SITE 177 177 Proton acceptor (By similarity).
 BINDING 34 34 NAD (By similarity).
 BINDING 81 81 Substrate (By similarity).
 BINDING 87 87 Substrate (By similarity).
 BINDING 94 94 NAD (By similarity).
 BINDING 119 119 Substrate (By similarity).
 BINDING 153 153 Substrate (By similarity).
 BINDING 227 227 NAD (By similarity).  

Keyword

 Complete proteome; NAD; Oxidoreductase; Reference proteome; Tricarboxylic acid cycle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0030060; F:L-malate dehydrogenase activity; IEA:HAMAP.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006108; P:malate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR001252; Malate_DH_AS.
 IPR010097; Malate_DH_type1.
 IPR023958; Malate_DH_type1_bac.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00068; MDH 

PRINTS